Current Status of Transcranial Direct Current Stimulation in Posttraumatic Stress and Other Anxiety Disorders

Current Behavioral Neuroscience Reports
Benjamin M HampsteadMarom Bikson

Abstract

Several empirically supported treatments have been identified for post-traumatic stress disorder (PTSD), yet a sizable number of patients are either unable to tolerate these approaches or remain symptomatic following treatment. Transcranial direct current stimulation (tDCS) is a well-tolerated method of modulating neuronal excitability that may hold promise as a novel intervention in PTSD and related disorders. The current review summarizes literature on the disrupted neural circuitry in PTSD and discusses the rationale for the commonly targeted prefrontal cortex (PFC) as it relates to PTSD. We then review the few prior (case) studies that have evaluated tDCS in patients with PTSD (1 study) and other anxiety disorders (4 studies). There was considerable variability in both the methods/justification for selecting the targeted brain region(s) and the tDCS montage used, which obscured any clear trends in the data. Finally, we describe the rationale for our ongoing study that specifically targets the lateral temporal cortex as a method of treating the symptoms of hyperarousal and re-experiencing in PTSD. Overall, it is clear that additional work is needed to establish dosing (e.g., intensity and duration of sessions, number of sess...Continue Reading

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References

Dec 20, 1984·The Journal of Comparative Neurology·D G Amaral, J L Price
Nov 20, 1982·The Journal of Comparative Neurology·E J Mufson, M M Mesulam
Nov 20, 1982·The Journal of Comparative Neurology·M M Mesulam, E J Mufson
Mar 27, 2001·Nature·M C Anderson, C Green
Dec 1, 1963·Brain : a Journal of Neurology·W PENFIELD, P PEROT
Jan 13, 2004·Science·Michael C AndersonJohn D E Gabrieli
Jan 29, 2005·The American Journal of Psychiatry·Rebekah BradleyDrew Westen
Aug 8, 2006·Annals of the New York Academy of Sciences·J Douglas Bremner
Feb 3, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Jonathan I BissonStuart Turner
Jun 15, 2007·The International Journal of Neuropsychopharmacology·Paulo S BoggioFelipe Fregni
Apr 2, 2008·Journal of Affective Disorders·Grethe E Johnsen, Arve E Asbjørnsen
Apr 29, 2008·Journal of Neural Engineering·Abhishek DattaMarom Bikson
Jul 1, 2008·Brain Stimulation·Michael A NitscheAlvaro Pascual-Leone
Oct 29, 2010·Journal of Neural Engineering·B EngdahlA P Georgopoulos
Nov 30, 2010·NeuroImage·Franco CaudaAlessandro Vercelli
Feb 16, 2011·The International Journal of Neuropsychopharmacology·Andre Russowsky BrunoniFelipe Fregni
Feb 26, 2011·Neuropharmacology·Robin L AupperleMartin P Paulus
Mar 2, 2011·Neuropharmacology·Kelly SkeltonBekh Bradley-Davino
Mar 23, 2011·Neuropharmacology·Alan N Simmons, Scott C Matthews
May 20, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·M C W KroesC R Brewin
Jun 29, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Maricla TavantiNicola De Stefano
Nov 17, 2011·Restorative Neurology and Neuroscience·Michael A Nitsche, Walter Paulus
Jan 14, 2012·Psychological Reports·Jason GoodsonMark B Powers
Feb 9, 2012·Journal of Psychiatry & Neuroscience : JPN·Rebecca K SripadaIsrael Liberzon
Nov 23, 2012·Psychological Medicine·C BourneE A Holmes
Apr 17, 2013·NeuroImage·Emma G DuerdenMargot J Taylor
Jul 12, 2013·The Journal of Clinical Psychiatry·Bradley V WattsMatthew J Friedman
Aug 21, 2013·Biological Psychiatry·Pedro ShiozawaAndre Russowsky Brunoni
Jan 15, 2015·Brain Stimulation·Janardhanan C NarayanaswamyY C Janardhan Reddy

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