PMID: 22583428May 16, 2012Paper

Current status of tyrosine hydroxylase in management of Parkinson's disease

CNS & Neurological Disorders Drug Targets
Annaik Petithomme Feve

Abstract

Tyrosine hydroxylase (TH) is the rate limiting enzyme responsible for converting tyrosine to L-DOPA in the dopamine synthesis pathway. The pathophysiology of Parkinson's disease (PD) is largely due to the nigrostriatal dopaminergic system, with a decrease in TH activity, TH synthesis and TH mRNA in the striatum of PD and animal experimental models. TH is thus one of the main targets for gene therapy in PD. TH activity variations during L-DOPA and new antiparkinsonian treatments have been extensively studied. Pharmacological trials with neuroprotective treatments could modify these variations, suggesting a direct involvement of TH cells in the neurodegenerative process. α- Synuclein, the main component of Lewy bodies regulates the production of dopamine through its interaction with TH. Over-expression of α-synuclein reduces the levels of TH mRNA and protein in the brain and in this way links the histological description of PD and its pathological biochemistry.

Citations

Mar 7, 2013·CNS Neuroscience & Therapeutics·Khanh V Q Luong, Lan T H Nguyễn
Aug 30, 2012·Journal of Neuroscience Research·Khanh Vinh Quôc Luong, Lan Thi Hoàng Nguyên
Jul 22, 2014·Chembiochem : a European Journal of Chemical Biology·Werner J GeldenhuysMi Hee Lim
Jan 8, 2013·Journal of the American Chemical Society·Yi-Ping ChenChung-Yuan Mou
Mar 7, 2018·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Shaosong KuangXiaojiang Tang
Jul 14, 2019·Journal of Biomolecular Structure & Dynamics·Majid SharifiMojtaba Falahati
Apr 6, 2016·The Journal of Biological Chemistry·Arathy S KumarSuresh K Rayala
Dec 5, 2017·Experimental and Therapeutic Medicine·Yuan ChenNanchang Xie
Aug 17, 2020·Scientific Reports· RahulYasir Hasan Siddique
Jul 28, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Rasool HaddadiSara Ami Ahmadi

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