Current status on the evaluation and management of the highly sensitized kidney transplant recipient

Current Opinion in Nephrology and Hypertension
Vineeta Kumar

Abstract

In light of the recent changes to the kidney allocation system (KAS) and the observed increase in the rate of transplantation of the highly sensitized kidney transplant candidate, the evaluation and care of this population is a timely topic. In its first year, the new KAS has already realized one goal of improving the chances of transplanting the most highly sensitized patients in the waiting list. This has brought to the forefront the need for recipient readiness in this special population, as well as the need for histocompatibility labs and kidney transplant programs to align themselves with each other, and also with the requirements of the United Network for Organ Sharing, and increase proficiency in testing and data interpretation. This manuscript is a review of the literature as well as practice patterns as they relate to the changes in KAS and the observed outcome since the activation of the new KAS, with the ultimate goal of aiding in the development of a more unified approach in the care of this specialized population which will allow for interdisciplinary and cross centre dialogue to optimize long term care and outcomes. Here we will review the changes to the KAS as they affect the highly sensitized kidney transplant r...Continue Reading

References

Nov 12, 2016·Transplantation Reviews·Ben C Reynolds, Kathryn Tinckam
Jun 10, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A R TamburC Jacquelinet
Nov 22, 2019·World Journal of Transplantation·Maurizio Salvadori, Aris Tsalouchos

Citations

Aug 31, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R A BrayH M Gebel
Mar 21, 2009·Transplantation Reviews·Kathryn Tinckam
Jun 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E S KrausR A Montgomery
Aug 20, 2010·Current Opinion in Nephrology and Hypertension·H M Gebel, R A Bray
May 20, 2011·The New England Journal of Medicine·Michael J HanawayINTAC Study Group
Jun 15, 2011·Current Opinion in Organ Transplantation·R A MontgomeryA M Jackson
Jul 29, 2011·The New England Journal of Medicine·R A MontgomeryD L Segev
May 17, 2014·Journal of the American Society of Nephrology : JASN·Ajay K IsraniBertram L Kasiske
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Nov 20, 2014·Nephrology·Linda CantwellPaolo Ferrari
Jan 22, 2015·Transplantation·Wenhao LiuMarc L Melcher
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May 4, 2015·British Medical Bulletin·Stanley C JordanAshley Vo

Related Concepts

Transplanted Kidney
alemtuzumab
Creatinine
Diagnostic Radiology Modality
Decreased Immunologic Activity [PE]
Histocompatibility
Immunoglobulin Activity
Mycophenolate
Blood Vessel
Mycophenolate mofetil

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