Current strategies exploiting NK-cell therapy to treat haematologic malignancies

International Journal of Immunogenetics
Jenna K Johnson, Jeffrey S Miller

Abstract

Natural killer (NK) cells recognize targets that have been changed via malignant transformation or infection. Previously, NK cells were thought to be short-lived, but we now know that NK cells can be long-lived and remember past exposures in response to CMV. NK cells use a plethora of activating and inhibitory receptors to recognize these changes and attack targets, but tumour cells often evade NK cells. Therefore, major efforts are being made to hone in on NK cell antitumour properties in immunotherapy. In the clinical setting, haploidentical NK cells can be adoptively transferred to help treat cancer. To expand NK cells in vivo and enhance tumour targeting, IL-15 is being tested in combination with a glycogen synthase kinase (GSK) 3 inhibitor (CHIR99021), an inhibitor that has been shown to expand mature, highly functional NK cells capable of killing multiple tumour targets. One major limitation to NK cell therapy is lack of specificity. To address this concern, bispecific or trispecific engagers that target NK cells to the tumour and an ADAM17 inhibitor that prevents CD16 shedding after NK cell activation are being tested. Additionally, monoclonal antibodies are being designed to redirect the inhibitory signals that limit NK...Continue Reading

References

Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·R B HerbermanD H Lavrin
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·V ScrepantiA Grandien
Oct 10, 2001·European Journal of Immunology·R JacobsR E Schmidt
Oct 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·SangKon OhJay A Berzofsky
Dec 21, 2004·Molecular Immunology·Mark J SmythYoshihiro Hayakawa
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Petter S WollDan S Kaufman
Oct 19, 2005·The Journal of Experimental Medicine·François GhiringhelliLaurence Zitvogel
Apr 12, 2006·The Journal of Experimental Medicine·Aharon G FreudMichael A Caligiuri
Aug 12, 2006·Immunity·Nicolas AnfossiEric Vivier
Nov 25, 2006·Nature Reviews. Immunology·Ilia VoskoboinikJoseph A Trapani
Apr 22, 2008·Nature Immunology·Lewis L Lanier
Dec 24, 2008·The Journal of Experimental Medicine·Nicholas D HuntingtonJames P Di Santo
Jan 13, 2009·Nature·Joseph C SunLewis L Lanier
Apr 23, 2009·Cancer Research·Hiroyuki FujisakiDario Campana
Jan 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey E RubnitzWing Leung
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sandra Lopez-VergèsLewis L Lanier
Aug 31, 2012·The New England Journal of Medicine·Jeffrey M VenstromKatharine C Hsu
Oct 19, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bree FoleyJeffrey S Miller
Jan 10, 2013·Annual Review of Immunology·David H RauletHeiyoun Jung
Jan 25, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tianxiang ZhangSungjin Kim
May 22, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andres WiernikJeffrey S Miller
Apr 18, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deborah W HendricksLewis L Lanier

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Citations

Dec 26, 2018·Expert Opinion on Biological Therapy·Kejian WangHuang Zhu
Jan 11, 2019·Cancers·Alexander David Barrow, Marco Colonna
Apr 18, 2019·Journal of Cellular Physiology·Behnaz ValipourHojjatollah Nozad Charoudeh
Oct 10, 2018·Frontiers in Immunology·Dorian StolkMark A Exley
Dec 11, 2019·The Journal of Experimental Medicine·Thomas A WaldmannKevin C Conlon

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