Current Strategies to Inhibit High Affinity FcεRI-Mediated Signaling for the Treatment of Allergic Disease

Frontiers in Immunology
Gregorio Gomez

Abstract

Allergies and asthma are a major cause of chronic disease whose prevalence has been on the rise. Allergic disease including seasonal rhinitis, atopic dermatitis, urticaria, anaphylaxis, and asthma, are associated with activation of tissue-resident mast cells and circulating basophils. Although these cells can be activated in different ways, allergic reactions are normally associated with the crosslinking of the high affinity Fc receptor for Immunoglobulin E, FcεRI, with multivalent antigen. Inflammatory mediators released from cytoplasmic granules, or biosynthesized de novo, following FcεRI crosslinking induce immediate hypersensitivity reactions, including life-threatening anaphylaxis, and contribute to prolonged inflammation leading to chronic diseases like asthma. Thus, inappropriate or unregulated activation of mast cells and basophils through antigenic crosslinking of FcεRI can have deleterious, sometimes deadly, consequences. Accordingly, FcεRI has emerged as a viable target for the development of biologics that act to inhibit or attenuate the activation of mast cells and basophils. At the forefront of these strategies are (1) Anti-IgE monoclonal antibody, namely omalizumab, which has the secondary effect of reducing FcεR...Continue Reading

References

May 1, 1992·The Journal of Experimental Medicine·T BieberC de la Salle
May 1, 1992·The Journal of Experimental Medicine·B WangG Stingl
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K FuruichiC Isersky
Feb 1, 1995·The Journal of Clinical Investigation·M DaëronW H Fridman
Jul 3, 1998·American Journal of Respiratory Cell and Molecular Biology·A M CampbellJ Bousquet
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·H E JungingerJ C Verhoef
Apr 9, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A S GounniQ Hamid
Jun 29, 2002·Nature Immunology·Valentino ParraviciniJuan Rivera
Sep 10, 2002·Molecular Immunology·Reuben P SiraganianKiyonao Sada
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Barbara FosterCalman Prussin
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Calman PrussinThomas B Casale
Jun 3, 2004·The Journal of Experimental Medicine·Sandra OdomJuan Rivera
Aug 19, 2004·The Journal of Allergy and Clinical Immunology·Ke ZhangAndrew Saxon
Sep 10, 2004·The Journal of Allergy and Clinical Immunology·Lisa A BeckSarbjit Saini
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abdelilah Soussi GounniBouchaib Lamkhioued
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregorio GomezJuan Rivera
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei ZhaoLawrence B Schwartz
Dec 21, 2006·Biochemistry·Junan LiMing-Daw Tsai
Mar 6, 2007·The Journal of Allergy and Clinical Immunology·Taku Kambayashi, Gary A Koretzky
Apr 18, 2007·Nature Reviews. Immunology·Stefan Kraft, Jean-Pierre Kinet
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregorio GomezLawrence B Schwartz
Dec 8, 2007·Nature Reviews. Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Feb 14, 2008·The Journal of Allergy and Clinical Immunology·Jonathan CorrenAlkis Togias
Jul 16, 2008·Drug Discovery Today·Michael T StumppPatrick Amstutz
Aug 30, 2008·Biochemical and Biophysical Research Communications·Lei ZhengYajun Guo
Aug 18, 2009·Journal of Molecular Biology·Alexander EggelMonique Vogel
Aug 3, 2010·Immunology Letters·Michael J BaumannMonique Vogel
May 7, 2011·The Journal of Allergy and Clinical Immunology·Kari C NadeauDale T Umetsu
Jan 20, 2012·The Journal of Allergy and Clinical Immunology·Seung Y ChuJohn R Desjarlais
May 9, 2012·Nature Medicine·Stephen J Galli, Mindy Tsai

❮ Previous
Next ❯

Citations

Jun 15, 2019·International Journal of Molecular Sciences·Sun-Young Kwon, Jae-Hong Kim
Jun 14, 2019·Expert Opinion on Biological Therapy·Erminia RidoloCristoforo Incorvaia
Jan 28, 2020·Annual Review of Immunology·Shiteng Duan, James C Paulson
Dec 14, 2019·Journal of Clinical Pathology·Omar E MohamedMamidipudi Thirumala Krishna
May 10, 2020·Expert Opinion on Biological Therapy·Bettina Wedi
Feb 23, 2020·Clinical Reviews in Allergy & Immunology·Daniel Elieh Ali KomiIan M Adcock
Sep 26, 2019·Frontiers in Immunology·Lennart M Roesner, Thomas Werfel
Sep 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jae Yeon LeeJoa Sub Oh
Jan 5, 2021·Frontiers in Immunology·Melanie C DispenzaDonald W MacGlashan
Feb 26, 2021·ImmunoTargets and Therapy·Bettina Wedi, Stephan Traidl
Nov 2, 2020·Pharmacology & Therapeutics·Guido H FaldutoAna Olivera
Aug 17, 2021·Frontiers in Immunology·Utpal Kumar AdhikariMourad Tayebi

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

Current Opinion in Allergy and Clinical Immunology
Tara Shankar, Andrej A Petrov
The World Allergy Organization Journal
Manav SegalThomas B Casale
Journal of the European Academy of Dermatology and Venereology : JEADV
J GerickeM Metz
The Cochrane Database of Systematic Reviews
S WalkerE H Walters
The Cochrane Database of Systematic Reviews
S WalkerE H Walters
© 2022 Meta ULC. All rights reserved