Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration

Stem Cells International
Yoojun NamJi Hyeon Ju

Abstract

The process of cartilage destruction in the diarthrodial joint is progressive and irreversible. This destruction is extremely difficult to manage and frustrates researchers, clinicians, and patients. Patients often take medication to control their pain. Surgery is usually performed when pain becomes uncontrollable or joint function completely fails. There is an unmet clinical need for a regenerative strategy to treat cartilage defect without surgery due to the lack of a suitable regenerative strategy. Clinicians and scientists have tried to address this using stem cells, which have a regenerative potential in various tissues. Cartilage may be an ideal target for stem cell treatment because it has a notoriously poor regenerative potential. In this review, we describe past, present, and future strategies to regenerate cartilage in patients. Specifically, this review compares a surgical regenerative technique (microfracture) and cell therapy, cell therapy with and without a scaffold, and therapy with nonaggregated and aggregated cells. We also review the chondrogenic potential of cells according to their origin, including autologous chondrocytes, mesenchymal stem cells, and induced pluripotent stem cells.

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Citations

Jul 12, 2019·The Veterinary Quarterly·Mudasir Bashir GugjooKuldeep Dhama
Oct 4, 2019·Therapeutic Advances in Musculoskeletal Disease·Youshui GaoChangqing Zhang
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Feb 26, 2021·Stem Cells International·Shuangpeng JiangQuanyi Guo
Apr 4, 2021·International Journal of Molecular Sciences·Sunhee JangJi Hyeon Ju
Jun 3, 2021·Pharmaceutics·Yeri Alice RimJi Hyeon Ju
Jul 3, 2021·International Journal of Molecular Sciences·Roxanne N StoneJulia Thom Oxford
Dec 7, 2019·ACS Applied Materials & Interfaces·Mantosh Kumar SatapathyChih-Hwa Chen
Aug 21, 2021·Frontiers in Cell and Developmental Biology·Zihao LiLunhao Bai
Jul 1, 2020·ACS Applied Materials & Interfaces·Xuan ZhouLijie Grace Zhang
Sep 3, 2021·The Journal of Hand Surgery, European Volume·Jason WongSimon Farnebo
Sep 18, 2021·Stem Cell Reviews and Reports·Jennifer Yejean KimJi Hyeon Ju
Jan 16, 2022·Clinical Reviews in Allergy & Immunology·Xiufen ZhuangYanhong Wu

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Methods Mentioned

BETA
biopsy
biopsies
chemical treatments

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