Current Therapy of Drugs in Amyotrophic Lateral Sclerosis

Current Neuropharmacology
Haiyan LuXiao-Ping Wang

Abstract

Amyotrophic lateral sclerosis (ALS), commonly termed as motor neuron disease (MND) in UK, is a chronically lethal disorder among the neurodegenerative diseases, meanwhile. ALS is basically irreversible and progressive deterioration of upper and lower motor neurons in the motor cortex, brain stem and medulla spinalis. Riluzole, used for the treatment of ALS, was demonstrated to slightly delay the initiation of respiratory dysfunction and extend the median survival of patients by a few months. In this study, the key biochemical defects were discussed, such as: mutant Cu/Zn superoxide dismutase, mitochondrial protectants, and anti-excitotoxic/ anti-oxidative / antiinflammatory/ anti-apoptotic agents, so the related drug candidates that have been studied in ALS models would possibly be further used in ALS patients.

Citations

Apr 28, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David B BanksRonald E Cannon
Feb 8, 2020·Indian Journal of Pharmacology·Gitika BatraBikash Medhi
Oct 8, 2016·Journal of Cellular Biochemistry·Thangavelu Soundara RajanOriana Trubiani
May 22, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·D Michal FreedmanRuth M Pfeiffer
May 16, 2019·Antioxidants & Redox Signaling·Elsa Cortés-MonteroJavier Garzón
Oct 7, 2020·International Journal of Molecular Sciences·María Rodríguez-MuñozPilar Sánchez-Blázquez
Dec 5, 2020·Oxidative Medicine and Cellular Longevity·Teresa Cunha-OliveiraFilomena S G Silva
Apr 4, 2021·International Journal of Molecular Sciences·Serena SilvestroEmanuela Mazzon
Feb 8, 2020·Current Neuropharmacology·Shareen Singh, Thakur Gurjeet Singh
Jul 3, 2021·International Journal of Molecular Sciences·Christine Péladeau, Jagdeep K Sandhu
Aug 11, 2021·Translational Neurodegeneration·Xiaojiao XuSheng Chen

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Methods Mentioned

BETA
transgenic

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