PMID: 9555536Apr 29, 1998Paper

Current therapy of small cell lung cancer

Current Opinion in Oncology
M SorensenH H Hansen

Abstract

This article reviews the most important recent clinical trials on the treatment of small cell lung cancer (SCLC). Two randomized studies addressing the timing of thoracic radiotherapy in limited stage SCLC are discussed. In the smaller of the two studies (n = 103), a survival benefit was associated with initial versus delayed radiotherapy. No survival differences in the larger study of the two studies were detected, which compared alternating with sequential delivery of radiotherapy (n = 335). The optimal way to deliver radiotherapy still must be defined. Two small, randomized studies on dose intensity with the use of growth factor support in patients with extensive disease reached conflicting results. Two randomized trials including patients with poor prognosis were discontinued prematurely, owing to interim analyses reporting a significant disadvantage in survival associated with oral single-agent etoposide compared with intravenous multiagent treatment. Thus, oral etoposide has a very limited role as single-agent treatment in the palliative setting. Convincing data have emerged regarding the camptothecins. Randomized studies of both the camptothecins and the taxanes in combination with established drugs are awaited with inte...Continue Reading

Citations

Sep 27, 2006·Pituitary·Joseph E Ippolito
Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Joseph E IppolitoJeffrey I Gordon
Mar 21, 2002·Cancer Investigation·Jason P ThomasUNKNOWN Ohio State University Phase II Research Consortium Study
Sep 3, 1999·Mayo Clinic Proceedings·A A AdjeiJ A Bonner

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