[Current therapy options in recurrent head and neck cancer].

HNO
A BoehmA Dietz

Abstract

Recurrent disease is one of the main reasons for the persistently poor prognosis of squamous cell carcinoma of the head and neck (HNSCC; European 5-year survival, 42%). The main treatment option for primary and secondary malignancy as well as recurrent disease is surgical therapy. If R0 resection (resection margin >5 mm) for a primary tumor is not viable, survival probability is reduced by 50%. In recurrent or secondary tumors with R1- or -2 resection or in the presence of non-resectable metastases, a palliative situation results in more than 80% of cases. In the case of surgery following radiotherapy or radiochemotherapy, attention should be paid to the criteria for salvage surgery (tissue perfusion, fibrosis, wound healing) and the procedure adapted to focus on functionality. In the case of relapse, primary surgery can potentially be supplemented with adjuvant therapy protocols such as (re-) irradiation, as well as possibly with chemotherapeutic agents or targeted therapies. Interdisciplinary collaboration and case discussions should take place in the context of a tumor board.

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Citations

Feb 28, 2014·International Journal of Computer Assisted Radiology and Surgery·Jens MeierThomas Neumuth
Apr 15, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Anja PickhardRudolf Reiter
Mar 21, 2015·The American Journal of Pathology·Zaki ShaikhibrahimSven Perner
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Jan 26, 2021·Clinical Nutrition ESPEN·Marília de Melo Freire LyraNassib Bezerra Bueno
Apr 15, 2011·Current Opinion in Oncology

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