PMID: 16518076Mar 7, 2006Paper

Current topics in pharmacological research on bone metabolism: inhibitory effects of bisphosphonates on the differentiation and activity of osteoclasts

Journal of Pharmacological Sciences
Keiko SuzukiHisashi Shinoda

Abstract

Despite the extensive use of bisphosphonates (BPs) in the treatment of metabolic bone diseases associated with increased osteoclastic bone resorption, the precise mechanism of their action on bone metabolism is still unclear. To clarify at which stages of osteoclast differentiation and activation that BPs influence, we examined the osteoclasts generated from mononuclear precursors and osteoclasts in the calvaria by laser scanning confocal microscopy. The studies showed that BPs inhibit lipopolysaccharide- or parathyroid hormone-induced osteoclast differentiation, fusion, attachment, actin ring formation, and activation and that both beta3 integrin and osteopontin have an important role in cytoskeletal rearrangements associated with cell attachment and resorption in osteoclasts.

References

Dec 1, 1991·The Journal of Clinical Investigation·M SatoG A Rodan
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F P ReinholtD Heinegård
Oct 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M G Cecchini, H Fleisch
Feb 1, 1990·The Journal of Clinical Investigation·A CaranoH C Blair
Jan 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Sato, W Grasser
Oct 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S E PapapoulosO L Bijvoet
Apr 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C W LöwikO L Bijvoet
Apr 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M G CecchiniP H Cooper
Jan 1, 1973·Calcified Tissue Research·Z B FriedenbergC T Brighton
Jan 1, 1980·Calcified Tissue International·C M PlasmansT J Slooff
Nov 1, 1994·Calcified Tissue International·K SelanderH K Väänänen
Nov 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R GravelS J Dixon
May 1, 1993·The Journal of Clinical Investigation·M SahniT J Martin
Oct 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D E HughesB F Boyce
Jun 13, 1998·The Journal of Biological Chemistry·M ChellaiahK Hruska
Feb 23, 2000·The Journal of Clinical Investigation·K P McHughS L Teitelbaum
Jun 8, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·L T DuongG A Rodan
Aug 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F P CoxonM J Rogers
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K SuzukiJ Sodek
Dec 7, 2002·Calcified Tissue International·M A Chellaiah, K A Hruska
Oct 8, 2003·Current Pharmaceutical Design·Michael J Rogers
Aug 10, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Keiko SuzukiHisashi Shinoda

❮ Previous
Next ❯

Citations

Dec 8, 2010·Immunologic Research·Makoto Inoue, Mari L Shinohara
Jul 10, 2013·Calcified Tissue International·Gemma MarcucciMaria Luisa Brandi
Sep 29, 2011·Journal of Pharmaceutical Sciences·Yunlong ZhengMitsuru Hashida
Sep 29, 2015·Oral and Maxillofacial Surgery Clinics of North America·Tara AghalooSotirios Tetradis
Oct 12, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tara L AghalooSotirios Tetradis
Apr 24, 2008·Journal of Pharmacological Sciences·Hisashi ShinodaShoji Yamada
Feb 1, 2010·Therapeutic Advances in Musculoskeletal Disease·René Rizzoli
May 18, 2007·Journal of Cellular Physiology·V SamannaM A Chellaiah
Sep 15, 2006·American Journal of Physiology. Cell Physiology·Mikiko ItoKen-ichi Miyamoto
Jul 26, 2011·Journal of Biomaterials Science. Polymer Edition·Elisabetta CenniNicola Baldini
Jan 18, 2017·Journal of Immunology Research·Nausicaa ClementeAnnalisa Chiocchetti
Feb 4, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maha HussainUNKNOWN PERSEUS Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Elisabeth J SmithEdith M Gardiner
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
F P CoxonM J Rogers
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Elisabeth J SmithEdith M Gardiner
© 2021 Meta ULC. All rights reserved