Current Treatment Modalities of JIA-associated Uveitis and its Complications: Literature Review

Ocular Immunology and Inflammation
Khawla Abu SamraC Stephen Foster

Abstract

Uveitis is a common and serious complication of juvenile idiopathic arthritis. Up to 75% of all cases of anterior uveitis in childhood are associated with juvenile idiopathic arthritis. Despite the remarkable progress in early detection and treatment of inflammation, vision-threatening complications of uveitis still occur in almost 60% of patients. Structural complications include band keratopathy, maculopathy (macular edema, macular cysts, and epiretinal membrane), glaucomatous optic neuropathy, and cataracts. The management of complications in juvenile idiopathic arthritis is usually complex and requires early surgical intervention. In this paper, we review the general concepts of common ocular complications seen in patients with JIA-associated uveitis, with special attention to the recent diagnostic and preferred treatment approaches at the Massachusetts Eye Research and Surgery Institution. Received 9 March 2015; revised 30 September 2015; accepted 30 October 2015; published online 14 January 2016.

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Citations

Jul 30, 2016·Ocular Immunology and Inflammation·Emmett T CunninghamManfred Zierhut
Mar 10, 2017·Expert Opinion on Investigational Drugs·Angela MauroRolando Cimaz
Jan 23, 2020·World Journal of Pediatrics : WJP·Ross E Petty, Qi Zheng
Nov 27, 2020·Frontiers in Pharmacology·Salmi Abdul RazakAdyani Md Redzuan
Mar 9, 2021·Therapeutic Advances in Ophthalmology·Judy L ChenEdmund Tsui

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