Current Treatment Options for Chronic Myeloid Leukemia Patients Failing Second-Generation Tyrosine Kinase Inhibitors

Journal of Clinical Medicine
Valentín García-Gutiérrez, Juan Carlos Carlos Hernández-Boluda

Abstract

Despite the excellent overall survival (OS) of patients with chronic myeloid leukemia (CML), a significant proportion will not achieve optimal response to imatinib or second-generation tyrosine kinase inhibitors (2GTKI). For patients with inadequate response to 2GTKIs, alternative 2GTKIs or ponatinib are widely available treatment options in daily clinical practice. Treatment decisions should be guided by correct identification of the cause of treatment failure and accurate distinction between resistant from intolerant or nonadherence patients. This review aims to provide practical advice on how to select the best treatment option in each clinical scenario.

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Citations

Feb 11, 2021·Blood Cancer Journal·Valentín Garcia-GutiérrezJuan Carlos Hernández-Boluda

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Clinical Trials Mentioned

NCT02467270
NCT03106779
NCT02885766
NCT02629692

Software Mentioned

BYOND

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