Current treatment options for idiopathic angioedema

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Jodi ShrobaJay Portnoy

Abstract

Idiopathic angioedema is defined as localized swelling of the cutaneous and mucosal tissue that occurs in episodes without a clear etiology. It can be problematic to treat when the underlying pathophysiology is not well understood. To identify successful treatments of idiopathic angioedema reported in the literature. A literature search was performed using PubMed. Published case reports and articles discussing treatment of idiopathic angioedema were used in the formulation of this review. In addition, 2 case reports are provided. Although there are no approved treatments for idiopathic angioedema, several medications used for the treatment of hereditary angioedema, such as bradykinin receptor antagonists (icatibant), kallikrein inhibitors (ecallantide), and C1 inhibitors, were successful in 10 patients. Anti-IgE monoclonal antibody (omalizumab) proved successful in 5 patients. The most widely used and successful medication was tranexamic acid (154 patients). Despite an unknown etiology, this article highlights viable treatment options for idiopathic angioedema. More clinical trials and better markers identifying the cause of angioedema are needed.

References

Jun 23, 1999·The American Journal of Medicine·M CicardiA Agostoni
Oct 25, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Lorenza C ZingaleMarco Cicardi
Oct 13, 2007·The Journal of Allergy and Clinical Immunology·Mark F SandsStanley A Schwartz
Apr 1, 2009·Allergy and Asthma Proceedings·Aleena Banerji, Albert L Sheffer
Oct 4, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sassan Ghazan-Shahi, Anne K Ellis
May 26, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Del CorsoP Migliorini
Mar 23, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C SauleA Gompel
Apr 12, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Antonie von WebskyKristine Breuer
May 28, 2013·The American Journal of Emergency Medicine·Vincenzo MontinaroLoreto Gesualdo
Aug 31, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tiffany Biason DyLarry Bernstein
Nov 23, 2013·The American Journal of Medicine·Konrad BorkJochen Hardt
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Alalia Berry, Rafael Firszt
Mar 29, 2014·Allergy·M CicardiUNKNOWN HAWK under the patronage of EAACI (European Academy of Allergy and Clinical Immunology)
May 9, 2014·Asia Pacific Allergy·Ayse Bilge Ozturk, Emek Kocaturk
Dec 3, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Matthew F FeldmanJonathan A Bernstein
Dec 3, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Mark C StahlJonathan A Bernstein

❮ Previous
Next ❯

Citations

Jan 3, 2016·Medicina intensiva·K NanwaniM Quintana-Díaz
May 29, 2016·The Medical Clinics of North America·Andrew G Ayars, Matthew C Altman
May 5, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carmela GravanteGianni Marone
Aug 27, 2016·British Dental Journal·M PatelS Dewhurst
Nov 9, 2016·Journal of Clinical Immunology·Charles FaisantLaurence Bouillet
Jun 16, 2017·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Brendan N Wong, Peter Vadas
Aug 25, 2018·Case Reports in Immunology·Enrico BrunettaGiorgio W Canonica
Sep 2, 2017·Clinical and Translational Allergy·Martin Christian BucherUrs Christian Steiner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Allergy and Clinical Immunology. in Practice
Alalia Berry, Rafael Firszt
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Shayna BurkeAndrew J MacGinnitie
The Annals of Pharmacotherapy
Sabrina W Cole, Lisa M Lundquist
The Journal of Allergy and Clinical Immunology
Mark F SandsStanley A Schwartz
© 2021 Meta ULC. All rights reserved