Current treatments and preventive strategies for radiation retinopathy

Current Opinion in Ophthalmology
David Reichstein

Abstract

Radiation retinopathy remains a devastating cause of visual morbidity in patients undergoing radiation for globe, orbit, and head and neck malignancies. This review discusses the recent efforts of several authors to treat radiation retinopathy once it has developed and efforts to prevent its development with early aggressive management. Intravitreal anti-vascular endothelial growth factor agents and intravitreal steroid agents have been used to successfully treat radiation-induced macular edema and neovascular events secondary to radiation retinopathy. The visual outcomes, however, have varied. Recent work has been directed towards prevention of radiation retinopathy prior to its development. This has been done with preventive scatter laser and intravitreal bevacizumab therapy. Effective customization of radiation dose to the tumor has also reduced some collateral radiation damage. Preventive vitrectomy and silicone oil placement at the time of plaque brachytherapy may shield normal ocular structures from radiation injury. Radiation retinopathy remains a major source of visual morbidity following radiotherapy for malignancies. Promising, albeit unproven, new therapies and preventive efforts may ameliorate the negative visual ou...Continue Reading

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Citations

Apr 27, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ira SeibelAntonia M Joussen
Nov 30, 2016·Current Eye Research·Murat Atabey ÖzerAzibe Yildiz
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Mar 19, 2019·Current Opinion in Ophthalmology·David Reichstein, Kayla Karan
Nov 9, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Amir MahdjoubiNathalie Cassoux
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Jul 13, 2018·Acta Ophthalmologica·Kalpana RoseChristopher Hudson
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Sep 13, 2020·Survey of Ophthalmology·Matteo FallicoMichele Reibaldi
Apr 6, 2021·Pediatric Blood & Cancer·Samir PatelAnita Mahajan
Jun 15, 2021·Advances in Radiation Oncology·Lawrence ChanJonathan C Horton

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Methods Mentioned

BETA
dot blot

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