Current Trends and Innovations in Bioanalytical Techniques of Metabolomics

Critical Reviews in Analytical Chemistry
Tianlei ZhangXijun Wang

Abstract

The advancement of omics technology has vigorously promoted the development of the life sciences; metabolomics in particular has emerged as a powerful tool that has a promising future in scientific research and clinical practice. As terminal products of complex biochemical networks, endogenous low-molecular-weight metabolites contain rich information about the physiological status of an individual or group of people. Also, this information has more practical significance in that we know "what happened" instead of "what might happen" to some degree. Rapid and accurate screening of metabolites on a large scale was beyond imagining in the past; however, benefiting from high-throughput technical means, the overall disturbance of metabolites induced by environmental stimulus or treatments can now be well analyzed. After appropriate bioinformatic analysis, clinically relevant biomarkers of a disease can be found, and an accurate and dynamic picture of metabolic disturbance that contributes to a phenotype of a certain organism can be constructed. Biomarkers can also reveal the general metabolic condition by pathways that correlate with disease progression, or even with the risk of certain diseases. Thus, as an indispensable part of th...Continue Reading

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Citations

Jul 30, 2020·Biotechnology Journal·Arvie Camille V de GuzmanShin Sik Choi
Nov 5, 2020·Critical Reviews in Analytical Chemistry·Jie Tang Han Han

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Methods Mentioned

BETA
nuclear magnetic resonance
electrophoresis
NMR
transgenic
liquid column chromatography
environmental stress

Software Mentioned

XCMS
TransOmics
Metabo
metaXCMS
Analyst

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