Current Trends in Biomaterial Utilization for Cardiopulmonary System Regeneration

Stem Cells International
Adegbenro Omotuyi John FakoyaJoshua Yusuf

Abstract

The cardiopulmonary system is made up of the heart and the lungs, with the core function of one complementing the other. The unimpeded and optimal cycling of blood between these two systems is pivotal to the overall function of the entire human body. Although the function of the cardiopulmonary system appears uncomplicated, the tissues that make up this system are undoubtedly complex. Hence, damage to this system is undesirable as its capacity to self-regenerate is quite limited. The surge in the incidence and prevalence of cardiopulmonary diseases has reached a critical state for a top-notch response as it currently tops the mortality table. Several therapies currently being utilized can only sustain chronically ailing patients for a short period while they are awaiting a possible transplant, which is also not devoid of complications. Regenerative therapeutic techniques now appear to be a potential approach to solve this conundrum posed by these poorly self-regenerating tissues. Stem cell therapy alone appears not to be sufficient to provide the desired tissue regeneration and hence the drive for biomaterials that can support its transplantation and translation, providing not only physical support to seeded cells but also chem...Continue Reading

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Citations

Jun 13, 2020·Frontiers in Bioengineering and Biotechnology·Marta Mazzola, Elisa Di Pasquale
Jul 9, 2020·APL Bioengineering·Aditya Kumar, Prashant Mali

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Methods Mentioned

BETA
homografts
bioprinting
chip
gene knockdown
chemical treatments

Clinical Trials Mentioned

NCT02057900

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