Current trends in needle-free jet injection: an update

Clinical, Cosmetic and Investigational Dermatology
Daniel Barolet, Antranik Benohanian

Abstract

Jet injection can be defined as a needle-free drug delivery method in which a high-speed stream of fluid impacts the skin and delivers a drug. Despite 75 years of existence, it never reached its full potential as a strategic tool to deliver medications through the skin. The aim of this review was to evaluate and summarize the evolution of jet injection intradermal drug delivery method including technological advancements and new indications for use. A review of the literature was performed with no limits placed on publication date. Needleless injectors not only reduce pain during drug delivery but also confine the drug more evenly in the dermis. Understanding skin properties of the injection site is a key factor to obtain optimal results as well as setting the right parameters of the jet injector. Until the advent of disposable jet injectors/cartridges, autoclaving of the injector remains the only reliable method to eliminate the risk of infection. Needle-free intradermal injection using corticosteroids and/or local anesthetics is well documented with promising indications being developed. Limitations of the review include low-quality evidence, small sample sizes, varying treatment parameters, and publication bias. New developm...Continue Reading

Citations

Apr 18, 2020·Dermatologic Therapy·Kwang Ho YooBeom Joon Kim
Jun 25, 2020·Pharmaceutics·Antonio José GuillotAna Melero
Aug 18, 2020·Journal of Cosmetic Dermatology·Yuri Vinshtok, Daniel Cassuto
Sep 10, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Osman Akyüz, Müslüm Ergün
Dec 4, 2019·Lasers in Surgery and Medicine·Andrés M ErlendssonAnthony M Rossi
Mar 21, 2020·Scientific Reports·Jan KrizekChristophe Moser
Mar 4, 2020·Contraception and Reproductive Medicine·G Anthony WilsonShaunta' M Chamberlin
Jun 12, 2020·Science Advances·Daniel Chin Shiuan LioChenjie Xu
Jan 21, 2021·Drug Design, Development and Therapy·Advait V BadkarMichael J LaBarre
Feb 4, 2021·Biomicrofluidics·Magalí Mercuri, David Fernandez Rivas
Jan 11, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yatish S Rane, Jeremy O Marston
Sep 17, 2020·Science Advances·Daniel Chin Shiuan LioChenjie Xu
Mar 9, 2021·Journal of Cosmetic Dermatology·Hye Sung HanBeom Joon Kim
Apr 17, 2021·International Journal of Pharmaceutics·Ruxuan WangJianqing Gao
May 3, 2021·International Journal of Pharmaceutics·Jan KrizekChristophe Moser
Jul 3, 2021·Drug Discovery Today·Dalinda EusébioÂngela Sousa
Sep 29, 2021·Expert Review of Vaccines·Vivek P ChavdaVasso Apostolopoulos
Dec 22, 2021·Lasers in Surgery and Medicine·Liora BikMartijn B A van Doorn

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