Current Trends of Essential Trace Elements in Patients with Chronic Liver Diseases.

Nutrients
Takashi Himoto, Tsutomu Masaki

Abstract

Essential trace elements play crucial roles in the maintenance of health, since they are involved in many metabolic pathways. A deficiency or an excess of some trace elements, including zinc, selenium, iron, and copper, frequently causes these metabolic disorders such as impaired glucose tolerance and dyslipidemia. The liver largely regulates most of the metabolism of trace elements, and accordingly, an impairment of liver functions can result in numerous metabolic disorders. The administration or depletion of these trace elements can improve such metabolic disorders and liver dysfunction. Recent advances in molecular biological techniques have helped to elucidate the putative mechanisms by which liver disorders evoke metabolic abnormalities that are due to deficiencies or excesses of these trace elements. A genome-wide association study revealed that a genetic polymorphism affected the metabolism of a specific trace element. Gut dysbiosis was also responsible for impairment of the metabolism of a trace element. This review focuses on the current trends of four trace elements in chronic liver diseases, including chronic hepatitis, liver cirrhosis, nonalcoholic fatty liver disease, and autoimmune liver diseases. The novel mechan...Continue Reading

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Citations

Mar 7, 2021·Antioxidants·Mariapia VairettiClarissa Berardo
May 1, 2021·Nutrients·Takashi Himoto
Aug 28, 2021·Nutrients·Maria TessitoreClaudia Mandato
Jul 8, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jennifer C LaiElizabeth J Carey

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Methods Mentioned

BETA
histone acetylation

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