Current trends of infectious complications following hematopoietic stem cell transplantation in a single center.

Journal of Korean Medical Science
Sun Hee ParkChun Choo Kim

Abstract

This study was to analyze the infectious complications after hematopoietic stem cell transplantation (HSCT) according to the recent changes of HSCT. Medical records of 379 adult patients who underwent HSCT consecutively at Catholic HSCT Center from January 2001 to December 2002 were reviewed retrospectively. Allogeneic HSCT accounted for 75.7% (287/379) and autologous HSCT for 24.3% (92/379). During pre-engraftment period, bacterial infection was predominant, and E. coli was still the most common organism. After engraftment, viral infection was predominant. The incidence of invasive fungal infection showed bimodal distribution with peak correlated with neutropenia and graft-versus-host disease (GVHD). The overall mortality and infection-related mortality rates according to 3 periods were as follows; during pre-engraftment, 3.16% (12/379) and 1.8% (7/379); during midrecovery period, 7.9% (29/367) and 4.1% (15/367); during late-recovery period, 26.9% (91/338), and 15.9% (54/338). Risk factors for infection-related mortality were as follows; during pre-engraftment period, fungal infection and septic shock; during the mid-recovery period, hemorrhagic cystitis and delayed engraftment; during the late-recovery period, fungal infectio...Continue Reading

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Citations

May 21, 2010·Clinical Transplantation·Almudena Martín-PeñaJosé Miguel Cisneros
Sep 25, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S-H KimW-S Min
Sep 1, 2006·International Journal of Antimicrobial Agents·Dong-Gun LeeDong-Seok Yim
Dec 12, 2012·Tuberculosis and Respiratory Diseases·Jae-Cheol KwonWoo-Sung Min
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Sep 25, 2008·Bone Marrow Transplantation·J-W Lee, C-C Kim
Jul 1, 2011·The Korean Journal of Internal Medicine·Dong-Gun LeeJung-Hyun Choi
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Apr 22, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Sergio M GomezLillian Sung
Oct 25, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Narendra AgrawalDinesh Bhurani

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Methods Mentioned

BETA
biopsy
MDS

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