Abstract
This study was to analyze the infectious complications after hematopoietic stem cell transplantation (HSCT) according to the recent changes of HSCT. Medical records of 379 adult patients who underwent HSCT consecutively at Catholic HSCT Center from January 2001 to December 2002 were reviewed retrospectively. Allogeneic HSCT accounted for 75.7% (287/379) and autologous HSCT for 24.3% (92/379). During pre-engraftment period, bacterial infection was predominant, and E. coli was still the most common organism. After engraftment, viral infection was predominant. The incidence of invasive fungal infection showed bimodal distribution with peak correlated with neutropenia and graft-versus-host disease (GVHD). The overall mortality and infection-related mortality rates according to 3 periods were as follows; during pre-engraftment, 3.16% (12/379) and 1.8% (7/379); during midrecovery period, 7.9% (29/367) and 4.1% (15/367); during late-recovery period, 26.9% (91/338), and 15.9% (54/338). Risk factors for infection-related mortality were as follows; during pre-engraftment period, fungal infection and septic shock; during the mid-recovery period, hemorrhagic cystitis and delayed engraftment; during the late-recovery period, fungal infectio...Continue Reading
References
Oct 1, 1974·Transplantation·H GlucksbergE D Thomas
Aug 1, 1980·The American Journal of Medicine·H M ShulmanE D Thomas
Feb 7, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H YooD J Kim
Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A DykewiczUNKNOWN American Society of Blood and Marrow Transplantation
Jul 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B ShiehC Li
Jul 13, 2001·Infectious Disease Clinics of North America·H L Leather, J R Wingard
Aug 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B A CollinR Ramphal
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
Feb 19, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Walter T HughesLowell S Young
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Per LjungmanCarlos Paya
May 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John R Wingard
May 17, 2002·The Korean Journal of Internal Medicine·Dong Gun LeeChun Choo Kim
Oct 24, 2002·Blood·Kieren A MarrLawrence Corey
Oct 24, 2002·Blood·Michael BoeckhLawrence Corey
Jan 9, 2003·Cancer·Lucia GomezCristina Estany
Sep 19, 2003·Annals of Hematology·Hermann EinseleUNKNOWN Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
Jun 3, 2004·The Lancet Infectious Diseases·Monique A S H Mennink-KerstenPaul E Verweij
Aug 3, 2004·Bone Marrow Transplantation·J-H YooC-C Kim
Nov 2, 2004·Bone Marrow Transplantation·A GratwohlUNKNOWN Accreditation Committee of the European Group for Blood and Marrow Transplantation
Dec 4, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dana JaffeGenovefa A Papanicolaou
Jan 18, 2005·Clinical Microbiology Reviews·Nina Singh, David L Paterson
Jan 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jin-Hong YooChun-Choo Kim
Feb 19, 2005·International Journal of Hematology·Su-Mi ChoiChun-Choo Kim
Mar 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stefan ReuterHeike von Baum
Citations
Nov 20, 2012·Annals of Hematology·Si-Hyun KimWoo-Sung Min
Oct 3, 2012·PloS One·Aziz HamadahJason Tay
Jun 23, 2009·Clinical Therapeutics·Hyun Soon SohnDonghwan Kim
May 21, 2010·Clinical Transplantation·Almudena Martín-PeñaJosé Miguel Cisneros
Sep 25, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S-H KimW-S Min
Sep 1, 2006·International Journal of Antimicrobial Agents·Dong-Gun LeeDong-Seok Yim
Mar 10, 2017·PloS One·Hyo-Jin LeeJung Im Jung
Nov 23, 2013·Infection & chemotherapy·Jae-Cheol KwonJin-Hong Yoo
May 31, 2011·Yonsei Medical Journal·Byung-Jin AhnSu-Mi Choi
Dec 12, 2012·Tuberculosis and Respiratory Diseases·Jae-Cheol KwonWoo-Sung Min
Nov 29, 2012·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Vivek B KuteHargovind L Trivedi
Sep 25, 2008·Bone Marrow Transplantation·J-W Lee, C-C Kim
Jul 1, 2011·The Korean Journal of Internal Medicine·Dong-Gun LeeJung-Hyun Choi
Sep 24, 2015·Terapevticheskiĭ arkhiv·V N VavilovB V Afanasyev
Apr 22, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Sergio M GomezLillian Sung
Mar 7, 2018·The Korean Journal of Internal Medicine·Sung-Yeon ChoDong-Gun Lee
Oct 25, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Narendra AgrawalDinesh Bhurani
Apr 30, 2021·Therapeutic Advances in Infectious Disease·Jyotsna KapoorNarendra Agrawal