Current trends to control fungal pathogens: exploiting our knowledge in the host-pathogen interaction

Infection and Drug Resistance
Laura C García-CarneroHéctor M Mora-Montes

Abstract

Human fungal infections remain a major challenge in medicine. Only a limited number of antifungal drugs are available, which are often related to severe adverse effects. In addition, there is an increased emergence related to resistant strains, which makes imperative to understand the host-pathogen interactions as well as to develop alternative treatments. Host innate and adaptive immunity play a crucial role controlling fungal infections; therefore, vaccines are a viable tool to prevent and treat fungal pathogens. Innate immunity is triggered by the interaction between the cell surface pattern recognition receptors (PRRs) and the pathogen-associated molecular patterns (PAMPs). Such an initial immunological response is yet little understood in fungal infections, in part due to the complexity and plasticity of the fungal cell walls. Described host cell-fungus interactions and antigenic molecules are addressed in this paper. Furthermore, antigens found in the cell wall and capsule, including peptides, glycoproteins, glycolipids, and glycans, have been used to trigger specific immune responses, and an increased production of antibodies has been observed when attached to immunogenic molecules. The recent biotechnological advances h...Continue Reading

Citations

Mar 12, 2019·Future Microbiology·José A Martínez-ÁlvarezHéctor M Mora-Montes
Jan 1, 2020·Current Protein & Peptide Science·Laura C García-CarneroAlma K Tamez-Castrellón
Dec 19, 2019·Frontiers in Microbiology·Marco J Hernández-ChávezHéctor M Mora-Montes
Feb 10, 2021·Journal of Fungi·Alison Felipe Alencar ChavesWagner Luiz Batista
Mar 5, 2021·NPJ Vaccines·Lorena V N OliveiraStuart M Levitz
May 13, 2021·F1000Research·Priscila Costa AlbuquerqueRodrigo Almeida-Paes

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