Current Understanding of Circulating Tumor Cells - Potential Value in Malignancies of the Central Nervous System

Frontiers in Neurology
Lukasz A AdamczykKathreena M Kurian

Abstract

Detection of circulating tumor cells (CTCs) in the blood via so-called "liquid biopsies" carries enormous clinical potential in malignancies of the central nervous system (CNS) because of the potential to follow disease evolution with a blood test, without the need for repeat neurosurgical procedures with their inherent risk of patient morbidity. To date, studies in non-CNS malignancies, particularly in breast cancer, show increasing reproducibility of detection methods for these rare tumor cells in the circulation. However, no method has yet received full recommendation to use in clinical practice, in part because of lack of a sufficient evidence base regarding clinical utility. In CNS malignancies, one of the main challenges is finding a suitable biomarker for identification of these cells, because automated systems, such as the widely used Cell Search system, are reliant on markers, such as the epithelial cell adhesion molecule, which are not present in CNS tumors. This review examines methods for CTC enrichment and detection, and reviews the progress in non-CNS tumors and the potential for using this technique in human brain tumors.

References

May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·E RacilaJ W Uhr
Jul 6, 2002·Critical Reviews in Oncology/hematology·Wen G JiangRobert E Mansel
Jun 5, 2003·Molecular Pathology : MP·C BöhmW Paulus
Nov 6, 2003·International Journal of Cancer. Journal International Du Cancer·José-Juan GaforioAna Lozano
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanna VonaPatrizia Paterlini-Bréchot
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Jeffrey AllardLeon W M M Terstappen
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Massimo CristofanilliLeon W M M Terstappen
Jun 7, 2005·Surgical Neurology·Pierre D MouradDaniel L Silbergeld
Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marija BalicRichard J Cote
Feb 3, 2007·Journal of Proteome Research·Fatima W KhwajaErwin G Van Meir
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine RiethdorfKlaus Pantel
Oct 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lyndsay HarrisUNKNOWN American Society of Clinical Oncology
Jul 4, 2008·The New England Journal of Medicine·Shyamala MaheswaranDaniel A Haber
Oct 7, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D J GallagherD F Bajorin
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-Yves PiergaMichel Marty
Dec 26, 2008·The New England Journal of Medicine·Anne C Chiang, Joan Massagué
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·AmirAli H TalasazRonald W Davis
Mar 14, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S J CohenN J Meropol
Mar 24, 2009·Electrophoresis·Peter R C GascoyneFrederick F Becker
Aug 14, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M U SchuhmannH Selle
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Dec 24, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emmanuelle Charafe-JauffretMax S Wicha
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Antoine-Emmanuel SalibaJean-Louis Viovy
Sep 15, 2010·PloS One·Elizabeth A PunnooseMark R Lackner
Sep 30, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Henry K LinRichard J Cote
Oct 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shannon L StottMehmet Toner
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Dan G DudaRakesh K Jain
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Max S Wicha, Daniel F Hayes
Apr 28, 2011·Nature Reviews. Clinical Oncology·Elizabeth ComenJoan Massagué
May 27, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Bahriye AktasPauline Wimberger
Nov 26, 2011·Breast Cancer Research : BCR·Natalia Bednarz-KnollKlaus Pantel
Jan 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jian-Mei HouCaroline Dive
Apr 25, 2012·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Catherine Alix-Panabières
Jun 9, 2012·The Lancet Oncology·Anthony LucciSavitri Krishnamurthy
Jul 6, 2012·Science Translational Medicine·David IssadoreHakho Lee
Aug 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liling ZhangKlaus Pantel
Sep 28, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Frank A W CoumansLeon W M M Terstappen
Oct 3, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C AggarwalS J Cohen
Dec 13, 2012·International Journal of Cancer. Journal International Du Cancer·Bianca MostertJohn W M Martens
Feb 14, 2013·Scientific Reports·Han Wei HouChwee Teck Lim
Mar 15, 2013·The New England Journal of Medicine·Sarah-Jane DawsonNitzan Rosenfeld
Apr 5, 2013·Science Translational Medicine·Emre OzkumurMehmet Toner

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Citations

Oct 1, 2016·Chonnam Medical Journal·Fariz NurwidyaFaisal Yunus
May 1, 2021·International Journal of Molecular Sciences·Severa BundaGelareh Zadeh
Feb 10, 2021·Neuro-oncology·Thais S SabedotHoutan Noushmehr

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Methods Mentioned

BETA
chips
flow cytometry
PCR
chip
density gradient centrifugation
biopsy

Software Mentioned

CellSearch
ISET
Cell Search

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