Current Understanding of Cytomegalovirus Reactivation in Critical Illness.

The Journal of Infectious Diseases
Hannah Imlay, Ajit P Limaye

Abstract

Cytomegalovirus (CMV) reactivation has been described in adults with critical illness caused by diverse etiologies, especially severe sepsis, and observational studies have linked CMV reactivation with worse clinical outcomes in this setting. In this study, we review observational clinical data linking development of CMV reactivation with worse outcomes in patients in the intensive care unit, discuss potential biologically plausible mechanisms for a causal association, and summarize results of initial interventional trials that examined the effects of CMV prevention. These data, taken together, highlight the need for a randomized, placebo-controlled efficacy trial (1) to definitively determine whether prevention of CMV reactivation improves clinical outcomes of patients with critical illness and (2) to define the underlying mechanism(s).

References

Oct 22, 1987·The New England Journal of Medicine·D R SnydmanA S Levey
Nov 15, 1993·Annals of Internal Medicine·D R SnydmanUNKNOWN Boston Center for Liver Transplantation CMVIG Study Group
Feb 1, 1993·Annals of Internal Medicine·J M GoodrichJ D Meyers
Sep 1, 1993·Journal of Virology·M BalthesenM J Reddehase
Aug 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E FalagasB G Werner
May 14, 1998·Anesthesiology·L PapazianF Gouin
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Mar 29, 2003·Journal of Virology·Teresa ComptonRobert W Finberg
Jul 9, 2003·Critical Care Medicine·Charles H CookRonald M Ferguson
Jan 13, 2005·Critical Care Medicine·Polly E ParsonsUNKNOWN NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network
Mar 8, 2006·Critical Care Medicine·Charles H CookRonald M Ferguson
May 23, 2006·The New England Journal of Medicine·UNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials NetworkAndrea L Harabin
Oct 24, 2008·Journal of Virology·Klas StrååtCecilia Söderberg-Nauclér
May 16, 2009·Critical Care : the Official Journal of the Critical Care Forum·Ryosuke Osawa, Nina Singh
Dec 17, 2009·Antiviral Research·Meghan R ForsterCharles H Cook
Mar 3, 2011·Critical Care : the Official Journal of the Critical Care Forum·Alexandra HeiningerKlaus Hamprecht
Apr 5, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Evgeny SenchenkovKaren Y Stokes
Jun 11, 2011·The Journal of Clinical Investigation·Michael Boeckh, Adam P Geballe
Apr 28, 2012·Combinatorial Chemistry & High Throughput Screening·Zheng QiuGhislain Opdenakker
Jun 12, 2013·Journal of Intensive Care Medicine·Giovanna Travi, Steven A Pergam
Nov 16, 2013·Nature Reviews. Immunology·Richard S HotchkissDidier Payen
Jun 12, 2014·PloS One·Andrew H WaltonRichard S Hotchkiss
Jun 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gloria EstesoHugh T Reyburn
Dec 19, 2014·Journal of Intensive Care·Seitaro Fujishima
Jul 16, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alda SaldanDavide Abate
Sep 30, 2015·Intensive Care Medicine·David S Y OngOlaf L Cremer
Oct 2, 2015·Intensive Care Medicine·Laurent PapazianJean-Marie Forel
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Aug 3, 2016·Critical Reviews in Immunology·Derek B DanahyThomas S Griffith
Oct 27, 2016·Immunological Reviews·Matthew J Delano, Peter A Ward
Jan 14, 2017·Frontiers in Microbiology·Wenjuan Tu, Sudha Rao
Feb 6, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David S Y OngUNKNOWN Molecular Diagnosis and Risk Stratification of Sepsis Consortium

❮ Previous
Next ❯

Citations

Jul 3, 2021·Journal of Clinical Medicine·Patrícia MonizPedro Póvoa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Danielle M ZerrWendy M Leisenring
© 2021 Meta ULC. All rights reserved