Current understanding of feline diabetes: part 1, pathogenesis

Journal of Feline Medicine and Surgery
J S Rand

Abstract

Type-1 diabetes, resulting from immune-mediated destruction of beta cells, appears to be rare in cats. Type-2 diabetes, characterised by inadequate insulin secretion and impaired insulin action, is the most common form of diabetes in cats. Other specific forms of diabetes constitute a substantial minority of cases. The most common is pancreatic destruction from pancreatic adenocarcinoma. Less frequent causes are insulin resistance from other endocrinopathies including acromegaly. Diabetes in cats is characterised by variable loss of insulin secretory capacity and insulin resistance. Glucose toxicity, islet amyloid-deposition, and pancreatitis contribute to further loss of beta cells and failure of insulin secretion. A significant number of cats undergo remission of their diabetes, usually 1-3 months after good glycaemic control is instituted. Obesity, old age, and Burmese breed are recognised risk factors for the development of diabetes in cats.

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Citations

Jul 28, 2016·Journal of Veterinary Internal Medicine·C GilorS P DiBartola
May 16, 2019·Journal of Feline Medicine and Surgery·Juliette BouillonKevin L Cosford
May 12, 2004·Journal of Feline Medicine and Surgery·S R StarkeyD B Church
Jul 7, 2007·Critical Reviews in Toxicology·T WangH M Mehendale
Jul 22, 2008·Journal of Feline Medicine and Surgery·Yaiza ForcadaLaura Blackwood
Jul 8, 2008·Journal of Feline Medicine and Surgery·Amy E DeClueCarol R Reinero
Dec 17, 2008·Journal of Feline Medicine and Surgery·Jenny-Ann L M ToribioRichard Malik
Aug 6, 2013·New Zealand Veterinary Journal·C A O'LearyJ S Rand
Nov 22, 2001·Journal of Feline Medicine and Surgery·G Martin, J Rand
Oct 22, 2002·Journal of Neuropathology and Experimental Neurology·Andrew P MizisinPaul A Cuddon
Jan 24, 2007·Acta Neuropathologica·Andrew P MizisinG Diane Shelton
Jul 24, 2003·Journal of the American Veterinary Medical Association·Kathleen A SennelloArthur M Siegel
Apr 24, 2007·Journal of Feline Medicine and Surgery·Annalisa PrahlLarry T Glickman
Jul 31, 2004·The Journal of Nutrition·Jacquie S RandRose Lederer
May 5, 2006·Veterinary Pathology·P RoccabiancaM Caniatti
Apr 3, 2007·Journal of the American Veterinary Medical Association·Nina AltClaudia E Reusch
Jan 15, 2015·The Journal of Small Animal Practice·L J Davison
Oct 7, 2008·Journal of Feline Medicine and Surgery·Tanya D HallLisa M Freeman
Jun 1, 2005·Journal of Feline Medicine and Surgery·Jelena M E RisticBriän Catchpole

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