Current understanding of HIF in renal disease

Kidney & Blood Pressure Research
Christian RosenbergerSamuel N Heyman

Abstract

Hypoxia-inducible factors (HIF) are ubiquitous transcription factors regulated by oxygen-dependent proteolysis, and hence rapidly mount an adaptational response to hypoxia. The HIF system is apparently more complex than initially considered in the perspective of the increasing number of HIF target genes, and the inter-relationship with various additional regulatory pathways. Regional hypoxia is believed to play a major role in renal disease. Experimental data confirm a role for HIF in renal pathophysiology. The discovery of HIF prolyl-hydroxylases as key enzymes of oxygen sensing and HIF proteolysis offer new possibilities to therapeutically target HIF. Herein, we review basic concepts of HIF regulation, and existing data on HIF activation in renal disease.

References

Oct 6, 1995·The Journal of Biological Chemistry·M L Norris, D E Millhorn
Mar 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S BachmannK U Eckardt
Aug 8, 1997·The Journal of Biological Chemistry·A RolfsR H Wenger
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·A D EckhartJ E Faber
Oct 31, 1998·Current Opinion in Genetics & Development·G L Semenza
Jan 14, 1999·Genes & Development·S BhattacharyaD M Livingston
Aug 14, 1999·The Journal of Biological Chemistry·C N Lok, P Ponka
Apr 25, 2000·The Journal of Biological Chemistry·C K MukhopadhyayP L Fox
May 9, 2000·The Journal of Biological Chemistry·Y TakahashiT Miura
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·R K Bruick
Dec 30, 2000·The Journal of Biological Chemistry·C ChenA Maity
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S Narravula, S P Colgan
Oct 13, 2001·Science·R K Bruick, S L McKnight
Nov 2, 2001·Biochemical and Biophysical Research Communications·D Y YoonO Hankinson
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D M StrokaD Candinas
Nov 8, 2001·European Archives of Psychiatry and Clinical Neuroscience·T KietzmannR Schmidt-Kastner
Nov 16, 2001·Biochemical and Biophysical Research Communications·M OikawaY Sato
Jan 16, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Annette ScheidMartin Meuli
Mar 9, 2002·Molecular and Cellular Biology·Tzipora ShoshaniElena Feinstein
Apr 3, 2002·Trends in Molecular Medicine·Gregg L Semenza
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Christian RosenbergerKai-Uwe Eckardt

❮ Previous
Next ❯

Citations

Nov 27, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Prabal K Chatterjee
Jul 11, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Carl M SheridanDavid Kent
Jun 26, 2008·Histochemistry and Cell Biology·Brigitte Kaissling, Michel Le Hir
Jun 3, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christian RosenbergerSamuel N Heyman
Mar 9, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xiaofang YuXiaoqiang Ding
Sep 28, 2006·Clinical and Experimental Pharmacology & Physiology·Christian RosenbergerSamuel N Heyman
Apr 5, 2011·Critical Care : the Official Journal of the Critical Care Forum·Samuel N HeymanChristian Rosenberger
Jul 20, 2006·Expert Opinion on Therapeutic Targets·Rachida S Bel AibaThomas Kietzmann
May 20, 2006·Kidney International·C RosenbergerS N Heyman
Oct 5, 2007·Kidney International·C RosenbergerS N Heyman
Jan 17, 2009·Kidney International·Ichiro KojimaMasaomi Nangaku
May 15, 2007·The Journal of Investigative Dermatology·Christian RosenbergerLawrence F Brown
Oct 7, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Terese KellenbergerBente Jespersen
Nov 6, 2018·Journal of Cellular Biochemistry·Krishnamurthy NakuluriAnil Kumar Pasupulati
Dec 22, 2006·Journal of the American Society of Nephrology : JASN·Christian RosenbergerPetra Reinke
May 2, 2013·Language, Speech, and Hearing Services in Schools·Stacy K BetzShanleigh F Sullivan
Dec 7, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Samuel N HeymanChristian Rosenberger
Nov 26, 2010·Therapeutic Drug Monitoring·Christina TsitsimpikouAristides Tsatsakis
Jun 15, 2007·Current Opinion in Nephrology and Hypertension

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.