Current understanding of magnetic resonance imaging biomarkers and memory in Alzheimer's disease

Alzheimer's & Dementia : Translational Research & Clinical Interventions
Ece BayramSarah J Banks

Abstract

Alzheimer's disease (AD) is caused by a cascade of changes to brain integrity. Neuroimaging biomarkers are important in diagnosis and monitoring the effects of interventions. As memory impairments are among the first symptoms of AD, the relationship between imaging findings and memory deficits is important in biomarker research. The most established magnetic resonance imaging (MRI) finding is hippocampal atrophy, which is related to memory decline and currently used as a diagnostic criterion for AD. While the medial temporal lobes are impacted early by the spread of neurofibrillary tangles, other networks and regional changes can be found quite early in the progression. Atrophy in several frontal and parietal regions, cortical thinning, and white matter alterations correlate with memory deficits in early AD. Changes in activation and connectivity have been detected by functional MRI (fMRI). Task-based fMRI studies have revealed medial temporal lobe hypoactivation, parietal hyperactivation, and frontal hyperactivation in AD during memory tasks, and activation patterns of these regions are also altered in preclinical and prodromal AD. Resting state fMRI has revealed alterations in default mode network activity related to memory i...Continue Reading

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Citations

Apr 29, 2020·Alzheimer's Research & Therapy·Peter N E YoungMichael Schöll
Oct 20, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Nicholas B RozemaCraig Weiss
Mar 26, 2019·Journal of Alzheimer's Disease : JAD·Hilkka LiedesUNKNOWN the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
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Jan 8, 2021·Alzheimer's Research & Therapy·Adeline Su Lyn NgJuan Helen Zhou
Jun 17, 2020·Journal of Alzheimer's Disease : JAD·Mario Hernandes-AlejandroJosé Luna-Muñoz
Aug 2, 2021·The Journal of Nervous and Mental Disease·Hui ZhangQi Guo

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