Current understanding of the aetiology and laboratory diagnosis of footrot

The Veterinary Journal
S A Wani, I Samanta

Abstract

Footrot is a highly contagious disease of the feet of ruminants caused by the synergistic action of certain bacterial species of which Dichelobacter nodosus (D. nodosus) is the main transmitting agent. The infection is specific to sheep and goats, although it has also been reported in cattle, horses, pigs, deer and mouflon. The antigenic diversity of D. nodosus is due to variations in the DNA sequence of its fimbrial subunit gene (fimA) and provides the basis for classification of the organism into at least 10 major serogroups (A-I and M), the distribution of which varies with different geographical locations. Host immune response to vaccination is serogroup specific. There are three different clinical forms of disease caused by virulent, intermediate and benign strains of D. nodosus, respectively. In order to facilitate rapid and reliable clinical diagnosis, virulence determination, strain differentiation and serogroup identification for effective control measures, immunological tests, DNA probes and PCR based techniques have been introduced. This review summarises the current understanding of the mechanisms of antigenic diversity of D. nodosus as well as advances made in its strain differentiation and diagnosis.

References

Mar 1, 1975·Journal of General Microbiology·T M Skerman
Jun 1, 1990·Australian Veterinary Journal·L J MooreJ R Egerton
Feb 1, 1991·Australian Veterinary Journal·D J MarshallM F Luff
Apr 1, 1991·Australian Veterinary Journal·D H ChetwinS E Thorley
Feb 16, 1985·The Veterinary Record·F Hindmarsh, J Fraser
Jul 1, 1974·Journal of Dental Research·R A Murphy
Jan 1, 1973·Journal of Comparative Pathology·J R Egerton
Jan 1, 1995·Research in Veterinary Science·R J Whittington, P J Nicholls
Jan 1, 1993·Annual Review of Microbiology·M S Strom, S Lory
Sep 1, 1995·Molecular Microbiology·N Firth, R A Skurray
Aug 1, 1996·Molecular Microbiology·H S Seifert
Dec 1, 1996·FEMS Microbiology Letters·S J BillingtonJ I Rood
Mar 1, 1997·Veterinary Microbiology·R J WhittingtonE K Moses
Jan 1, 1997·The Veterinary Journal·D Liu, W K Yong
Mar 3, 1998·The Veterinary Record·M A HurtadoS Vadillo
Feb 20, 1999·Molecular and Cellular Probes·G H JohnR P Ellis
Jan 5, 2002·Journal of Medical Microbiology·I DemirkanC A Hart
Dec 19, 2002·Veterinary Microbiology·Ruth M KennanJulian I Rood
Aug 6, 2004·Molecular and Cellular Probes·S A WaniA S Buchh

❮ Previous
Next ❯

Citations

Mar 9, 2010·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Wilson WongCorrine J Porter
Oct 13, 2011·The Journal of Biological Chemistry·Wilson WongCorrine J Porter
May 29, 2012·BMC Veterinary Research·Alessandro FoddaiJasmeet Kaler
Mar 31, 2012·Acta Veterinaria Scandinavica·Torunn RogdoTerje Fjeldaas
Jan 10, 2016·Anaerobe·Mohd MuzafarElizabeth M H Wellington
Jan 22, 2013·Veterinary Microbiology·Marianne GilhuusHannah J Jørgensen
Dec 20, 2011·Veterinary Microbiology·María LorenzoAlberto Quesada
May 21, 2011·Veterinary Microbiology·Ruth M KennanJulian I Rood
Feb 4, 2014·Journal of Wildlife Diseases·Sushan Han, Kristin G Mansfield
Aug 3, 2019·Animals : an Open Access Journal From MDPI·Athanasios I GelasakisIoannis Bossis
May 20, 2021·Veterinary Medicine·Haben Fesseha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.