Current understanding of the role of microRNAs in spinocerebellar ataxias

Cerebellum & Ataxias
E Koscianska, W J Krzyzosiak

Abstract

The number of studies highlighting the role of microRNAs (miRNAs) in human physiology and diseases is growing, but many miRNA-driven regulatory mechanisms remain elusive. A proper understanding of the exact functions of individual miRNAs and their interaction with specific targets is vitally important because such knowledge might help cure diseases for which no effective treatment currently exists. Herein, we present current views on the role of the miRNA-mediated regulation of gene expression in the case of select spinocerebellar ataxias (SCAs) and their potential involvement in the pathogenesis of these diseases. Specifically, we summarize published data showing the known links between miRNAs and CAG repeat-dependent SCAs. Moreover, using the example of SCA type 3 (SCA3), we refer to the issue of prediction and validation of miRNA targets, and we demonstrate that miR-181a-1 may regulate the 3'-UTR of the ATXN3 gene.

References

Dec 31, 2003·Cell·Benjamin P LewisChristopher B Burge
Oct 27, 2004·PLoS Biology·Bino JohnDebora S Marks
Apr 5, 2005·Nature Genetics·Azra KrekNikolaus Rajewsky
Jun 10, 2005·Nature·Jun LuTodd R Golub
Oct 6, 2005·Nature Reviews. Genetics·Jennifer R Gatchel, Huda Y Zoghbi
Feb 7, 2006·Cell Metabolism·Christine EsauBrett P Monia
Jul 18, 2006·Nucleic Acids Research·Jan Krüger, Marc Rehmsmeier
Oct 5, 2006·Molecular Cell·Julide BilenNancy M Bonini
Apr 3, 2007·Nature Genetics·Madhu S KumarTyler Jacks
Apr 10, 2007·Annual Review of Neuroscience·Harry T Orr, Huda Y Zoghbi
Jun 22, 2007·Nature·Sergei M Mirkin
Jul 4, 2007·The Journal of Experimental Medicine·Anne SchaeferPaul Greengard
Sep 20, 2007·BMC Molecular Biology·Edyta KoscianskaKriton Kalantidis
Sep 26, 2007·Nature Genetics·Michael KerteszEran Segal
Nov 10, 2007·Nucleic Acids Research·Sam Griffiths-JonesAnton J Enright
Dec 26, 2007·Methods : a Companion to Methods in Enzymology·Donald E KuhnTerry S Elton
Jul 30, 2008·Current Opinion in Neurobiology·Natascha Bushati, Stephen M Cohen
Aug 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey N SavasNaoko Tanese
Oct 30, 2008·The Journal of Biological Chemistry·Huda Y Zoghbi, Harry T Orr
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·V Narry KimMikiko C Siomi
Mar 4, 2009·Nature Cell Biology·Julia WinterSven Diederichs
Mar 10, 2009·Trends in Neurosciences·Sébastien S Hébert, Bart De Strooper
Mar 20, 2009·Human Molecular Genetics·Marc S Weinberg, Matthew J A Wood
Mar 28, 2009·International Journal of Molecular Sciences·Zhen LiuDecheng Yang
May 20, 2009·Current Opinion in Cell Biology·Marina Chekulaeva, Witold Filipowicz
Oct 14, 2009·Drug Discovery Today·Reema RoshanBeena Pillai
Jan 19, 2010·Seminars in Cell & Developmental Biology·Pierre Lau, Bart de Strooper
Feb 24, 2010·Nature Reviews. Molecular Cell Biology·Arturo López CastelChristopher E Pearson
Mar 30, 2010·Neuroscience Letters·A I PogueW J Lukiw
Apr 20, 2010·Trends in Neurosciences·Ling-Bo Li, Nancy M Bonini

❮ Previous
Next ❯

Citations

Feb 6, 2019·Molecular Neurobiology·Verónica M Borgonio-CuadraJonathan J Magaña
Aug 23, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anna Niewiadomska-Cimicka, Yvon Trottier
Jan 5, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ronald A M BuijsenWilleke M C van Roon-Mom
Jun 13, 2015·International Journal of Molecular Sciences·Martyna O UrbanekWlodzimierz J Krzyzosiak
Nov 28, 2017·Epigenomics·Hongmei LiuCaixia Guo
Jan 27, 2017·Biomarkers in Medicine·Vijitha ViswambharanAyyappan Anitha
Jul 6, 2019·Frontiers in Molecular Neuroscience·Xiaoyu Dong, Shuyan Cong
Feb 8, 2020·Current Neuropharmacology·Shareen Singh, Thakur Gurjeet Singh
Jul 3, 2021·International Journal of Molecular Sciences·Edyta KoscianskaAgnieszka Fiszer

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
transfection
immunoprecipitation
Assay

Software Mentioned

PicTar
TargetScan
PITA
miRbase
miRco
miRANDA
TargetScanHuman
RNAhybrid
MREdictor

Related Concepts

Related Feeds

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Related Papers

MicroRNA
Benjamin T Moore, Peng Xiao
Journal of Autoimmunity
Kaleb M PauleyEdward K L Chan
Annals of the New York Academy of Sciences
Kaleb M Pauley, Edward K L Chan
Electroencephalography and Clinical Neurophysiology. Supplement
T Klockgether, J Dichgans
© 2021 Meta ULC. All rights reserved