Curvature-mediated cooperative wrapping of multiple nanoparticles at the same and opposite membrane sides

Nanoscale
Zengshuai YanTongtao Yue

Abstract

Cell membrane interactions with nanoparticles (NPs) are essential to cellular functioning and mostly accompanied by membrane curvature generation and sensing. Multiple NPs inducing curvature from one side of a membrane are believed to be wrapped cooperatively by the membrane through curvature-mediated interactions. However, little is known about another biologically ubiquitous and important case, i.e., NPs binding to opposite membrane sides induce a curved bend of different directions. Combining coarse-grained molecular dynamics and theoretical analysis, here we systematically investigate the cooperative effect in the wrapping of multiple adhesive NPs at the same and opposite membrane sides and demonstrate the importance of the magnitude and direction of the membrane bend in regulating curvature-mediated NP interactions. Effects of the NP size, size difference, initial distance, number, and strength of adhesion with the membrane on the wrapping cooperativity and wrapping states are analyzed. For NPs binding to the same membrane side, rich membrane wrapping and NP aggregation states are observed, and the curvature-mediated interactions could be either attractive or repulsive, depending on the initial NP distance and the competit...Continue Reading

References

Jan 1, 1983·The Journal of Cell Biology·R M SteinmanZ A Cohn
Jul 31, 2003·Comptes rendus biologies·Jean-Baptiste FournierPaola Galatola
Dec 3, 2003·Science·Brian J PeterHarvey T McMahon
Mar 10, 2004·The European Physical Journal. E, Soft Matter·T R Weikl
Apr 20, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Markus Deserno
Dec 17, 2004·Physical Review Letters·Mohamed Laradji, P B Sunil Kumar
Feb 16, 2005·Nature Materials·Julian C Shillcock, Reinhard Lipowsky
Jun 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Huajian GaoLambert B Freund
Dec 2, 2005·Nature·Harvey T McMahon, Jennifer L Gallop
Dec 21, 2005·Nature Reviews. Molecular Cell Biology·Joshua Zimmerberg, Michael M Kozlov
Jun 30, 2006·Biophysical Journal·Ira R Cooke, Markus Deserno
Mar 21, 2007·The Journal of Cell Biology·Pieta K MattilaPekka Lappalainen
Aug 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Markus DesernoJemal Guven
Aug 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Martin Michael MüllerJemal Guven
Aug 7, 2007·Physical Review Letters·Andrea GrafmüllerReinhard Lipowsky
Sep 4, 2007·The Journal of Chemical Physics·Kurt A SmithAnna C Balazs
Jun 11, 2008·The Journal of Cell Biology·Oliver T Fackler, Robert Grosse
Apr 22, 2009·Cell·Adam FrostPietro De Camilli
Dec 22, 2009·Nature Cell Biology·Helge EwersLudger Johannes
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Sergey MkrtchyanJeff Z Y Chen
May 25, 2010·Nature Structural & Molecular Biology·Jay T Groves, John Kuriyan
Nov 26, 2010·Current Opinion in Cell Biology·Hongxia ZhaoPekka Lappalainen
Jan 12, 2011·Annual Review of Physical Chemistry·Tobias BaumgartSovan L Das
Sep 20, 2011·Nature Nanotechnology·Xinghua ShiHuajian Gao
Nov 4, 2011·Nano Letters·Robert VáchaDaan Frenkel
Dec 12, 2012·Physical Review Letters·Anđela Šarić, Angelo Cacciuto
Dec 12, 2012·Physical Review Letters·Amir Houshang BahramiThomas R Weikl
Mar 25, 2014·Soft Matter·Michael RaatzThomas R Weikl
Apr 8, 2014·Advances in Colloid and Interface Science·Amir H BahramiThomas R Weikl
Jul 16, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Xin Yi, Huajian Gao
Dec 23, 2014·Soft Matter·Xin Yi, Huajian Gao
Aug 11, 2015·ACS Nano·Sulin ZhangGang Bao
Oct 3, 2015·Nano Letters·Jaime Agudo-Canalejo, Reinhard Lipowsky
Oct 28, 2015·Soft Matter·Amir Houshang BahramiThomas R Weikl

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Citations

Jun 3, 2021·Journal of Chemical Theory and Computation·Sebastian Franco-UlloaMarco De Vivo
Oct 17, 2021·Physical Review. E·Zeming Wu, Xin Yi
Dec 7, 2021·Journal of Chemical Theory and Computation·Tongwei ChenHaojun Liang

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