Curve characteristics in monozygotic twins with adolescent idiopathic scoliosis: 3 new twin pairs and a review of the literature

Acta Orthopaedica Scandinavica
Lodewijk W van RhijnB E Veraart

Abstract

Most authors state that there is strong evidence for a genetic origin of adolescent idiopathic scoliosis (AIS). This conclusion is mainly based on the fact that the rate of concordance for AIS in monozygotic twins is significantly higher than that in dizygotic twins. However, it is of interest to determine whether all elements of scoliosis formation are genetically predetermined. If this were the case, there would perhaps be less place for closed treatment. We surveyed the literature for monozygotic twin pairs in which both members suffered from idiopathic scoliosis and added 3 pairs from our own patient group. The total group consisted of 32 twin pairs. We found that gender, direction of the convexity, the level of the apex and the kyphotic angle were determined more by genetic factors than the lateral Cobb angle of the scoliotic curve. This suggests that variations in the environment may affect the curve patterns in monozygotic twins.

References

Feb 1, 1979·Southern Medical Journal·R L Gaertner
Nov 1, 1990·The Journal of Bone and Joint Surgery. British Volume·A J Carr
Dec 1, 1967·Journal of Medical Genetics·F V De George, R L Fisher
Apr 18, 1998·The Journal of Bone and Joint Surgery. British Volume·M InoueH Moriya
Feb 1, 1958·The Journal of Bone and Joint Surgery. British Volume·A H R CODORNIU
Feb 1, 1958·The Journal of Bone and Joint Surgery. British Volume·R ESTEVE
Nov 1, 1959·The Journal of Bone and Joint Surgery. British Volume·G MURDOCH

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Citations

Jun 19, 2007·International Orthopaedics·Kenneth M C CheungKeith D K Luk
Sep 17, 2008·Spine·Eustathios KenanidisGeorge A Kapetanos
Jul 26, 2013·Spine·Mera K TilleyNancy H Miller
Mar 8, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Joris P S HermusAndré van Ooij
Jul 4, 2013·The Spine Journal : Official Journal of the North American Spine Society·Michiel M A JanssenRené M Castelein
Apr 29, 2010·American Journal of Medical Genetics. Part a·Kenneth WardRakesh Chettier
Feb 15, 2017·The Journal of Bone and Joint Surgery. American Volume·Kota WatanabeMorio Matsumoto
Jun 24, 2017·Acta ortopedica brasileira·Clarissa Miranda Carneiro de Albuquerque OlbertzJosé Lamartine de Andrade Aguiar
Jun 16, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiajun ZhangWayne Y W Lee
Feb 6, 2018·The Open Orthopaedics Journal·Maja Fadzan, Josette Bettany-Saltikov
Oct 19, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Huanxiong ChenJack C Y Cheng
Dec 29, 2007·Journal of Orthopaedic Surgery·G A DayB Brankoff
Jul 16, 2017·Archives of Orthopaedic and Trauma Surgery·Michal LatalskiP Zwolak
Oct 1, 2012·JBJS Case Connector·Tristan de MooijJohn Ham

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