Curvilinear relationship between blood lead level and reaction time. Differential association with blood lead fractions derived from exogenous and endogenous sources

Journal of Occupational and Environmental Medicine
M L BleeckerD P Ford

Abstract

Prior studies demonstrate an inconsistent relationship between occupational inorganic lead exposure and simple reaction time (SRT) performance. In this study, we administered a computerized SRT test to 78 currently employed lead smelter workers and then investigated the relationship between different measures of blood lead and components of SRT performance. The measures of blood lead included current blood lead (PbB) and mathematically derived blood lead fractions from the environment (PbB-env) and from bone (PbB-bn). Measures of SRT performance, obtained from 44 trials with interstimulus intervals (ISIs) ranging from 1 to 10 seconds, included median SRT (SRT-md), mean SRT for ISIs between 1 and 5 seconds (SRT-1-5), and mean SRT for ISIs between 6 and 10 seconds (SRT-6-10). Multiple regression analysis after adjustment for age and education revealed a curvilinear relationship between PbB and SRT-md. As PbB increased from 0 to 30 micrograms dl-1, SRT-md decreased, and only with PbB levels above 30 micrograms dl-1 did SRT-md increase. PbB terms accounted for 13.7% of the variance in this SRT measure (P < 0.01). The longer ISI variable, SRT-6-10, was found to be more strongly related to PbB, to have lesser variability across ISIs,...Continue Reading

References

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Citations

Jun 17, 2009·Journal of Occupational and Environmental Medicine·Huiling NieHoward Hu
Feb 23, 2005·Occupational and Environmental Medicine·M L BleeckerC G Vaughan
May 17, 2006·Journal of Agromedicine·Beth A BakerJean Small Johnson
Aug 28, 2010·Physiotherapy Theory and Practice·Shari L MaverHylton Menz
Jan 24, 2016·Ecotoxicology and Environmental Safety·Christina M BurdenBrian H Smith
Jun 28, 2002·Journal of Occupational and Environmental Medicine·Margit L BleeckerMichael J Tiburzi
Nov 12, 2003·Journal of Occupational and Environmental Medicine·Daniel RhodesHoward Hu
Apr 16, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Naila KhalilSteven R Cummings
Aug 19, 2009·Neurotoxicology and Teratology·Edward F KriegUNKNOWN CDC/NCI NHANES III Genomics Working Group

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