Curvularia fungi presenting as a large cranial base meningioma: case report

Neurosurgery
Harminder SinghJames Evans

Abstract

Fungal infections are emerging as a growing threat to human health, especially in immunocompromised patients. Candida, Cryptococcus, and Aspergillus are a few of the commonly encountered organisms leading to brain abscesses. In this report, we describe Curvularia geniculata as the causative agent in central nervous system infection. Our review of the literature did not reveal a similar published case of central nervous system infection with this organism. A 35-year-old African-American man presented with obstructive hydrocephalus from a large cranial base lesion. Imaging characteristics on computed tomographic and magnetic resonance imaging scans were consistent with those of a cranial base meningioma. The patient underwent an endoscopic transnasal/transclival approach to the anterior middle cranial base for biopsy and decompression of this lesion. A spindle cell proliferation was observed on frozen section, which favored a diagnosis of meningioma. However, on permanent sections, we identified fungal hyphae with budding. Subsequent biopsies grew Curvularia in fungal cultures. Deoxyribonucleic acid sequencing was used to confirm the identification of the isolate as Curvularia geniculata. Limited data are available for in vitro s...Continue Reading

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Citations

Oct 12, 2010·Clinical Microbiology Reviews·Sanjay G Revankar, Deanna A Sutton
Jul 31, 2013·World Neurosurgery·Branko SkovrljJoshua B Bederson
Oct 15, 2011·Medical Mycology Journal·Satoru Kikuchi
Sep 20, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nisha GadgilGanesh Rao
Apr 6, 2013·Diagnostic Microbiology and Infectious Disease·Keith C da CunhaJosep Guarro
Feb 4, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A ChowdharyM Cuenca-Estrella
Apr 9, 2021·Australian Veterinary Journal·T LiatisZ Polizopoulou
Apr 24, 2020·Journal de mycologie médicale·E DjenontinE Dannaoui

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