Cushing's syndrome - Disease monitoring: Recurrence, surveillance with biomarkers or imaging studies

Best Practice & Research. Clinical Endocrinology & Metabolism
Oskar Ragnarsson

Abstract

Pituitary surgery is the first-line treatment for patients with Cushing's disease. For patients who are not considered candidates for pituitary surgery, pituitary radiation and bilateral adrenalectomy are further treatment alternatives. Not all patients are cured with pituitary surgery, and a substantial number of patients develop recurrence, sometimes many years after an apparently successful treatment. The same applies to patients treated with radiotherapy. Far from all patients are cured, and in many cases the disease recurs. Bilateral adrenalectomy, although always curative, causes chronic adrenal insufficiency and the remaining pituitary tumour can continue to grow and cause symptoms due to pressure on adjacent tissues, a phenomenon called Nelson's syndrome. In this paper the rate of recurrence of hypercortisolism, as well as the rate of development of Nelson's syndrome, following treatment of patients with Cushing's syndrome, will be reviewed. The aim of the paper is also to summarize clinical and biochemical factors that are associated with recurrence of hypercortisolism and how the patients should be monitored following treatment.

References

Dec 1, 1983·Clinical Endocrinology·A A Kasperlik-ZałuskaB Migdalska
Jan 7, 1999·Clinical Endocrinology·M A PereiraB L Wajchenberg
Dec 14, 1999·World Journal of Surgery·S K NagesserC J van de Velde
Feb 13, 2001·Clinical Endocrinology·S A KeminkA G Smals
Mar 1, 1960·Annals of Internal Medicine·D H NELSONG W THORN
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Gary D HammerCharles B Wilson
Oct 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Guillaume AssiéXavier Bertagna
Feb 1, 2007·Surgery·Alejandra Gil-CárdenasJuan Pablo Pantoja
Aug 21, 2007·Surgical Endoscopy·A Gil-CárdenasM F Herrera
Oct 27, 2007·Neurosurgical Focus·Magdalena J Banasiak, Ali R Malek
Dec 7, 2007·The Journal of Clinical Endocrinology and Metabolism·Chirag G PatilEdward R Laws
Jan 10, 2008·Clinical Endocrinology·Daniella Jesus Patrick Carminatti RomanholiLuiz Roberto Salgado
Mar 13, 2008·The Journal of Clinical Endocrinology and Metabolism·Lynnette K NiemanVictor M Montori
Sep 6, 2008·Clinical Endocrinology·B AmbrosiC Dall'Asta
May 30, 2009·Journal of the American College of Surgeons·Philip W SmithJohn B Hanks
Jun 11, 2009·The Journal of Clinical Endocrinology and Metabolism·Frederic CastinettiThierry Brue
Jul 9, 2009·The Journal of Clinical Endocrinology and Metabolism·Marco LosaPietro Mortini
Nov 13, 2009·Neuroendocrinology·R A AlwaniR A Feelders
Jan 19, 2010·The Journal of Clinical Endocrinology and Metabolism·Elena ValassiAnne Klibanski
Jul 30, 2010·European Journal of Endocrinology·T M BarberJ A H Wass
Jan 5, 2011·The Journal of Clinical Endocrinology and Metabolism·R N ClaytonP W Jones
Sep 3, 2011·European Journal of Endocrinology·Roula Bou KhalilJérôme Bertherat
Mar 9, 2012·The Journal of Clinical Endocrinology and Metabolism·Maya LodishConstantine A Stratakis
Jan 3, 2013·Clinical Endocrinology·Mattia BarbotCarla Scaroni
Feb 2, 2013·European Journal of Endocrinology·Krystallenia I AlexandrakiAshley B Grossman
Feb 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Russell R LonserEdward H Oldfield
Feb 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Jessica K LambertEliza B Geer
Mar 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Olaf M DekkersHenrik Toft Sørensen
Aug 21, 2013·The Journal of Clinical Endocrinology and Metabolism·Katrin RitzelMartin Reincke
Aug 30, 2013·European Journal of Endocrinology·Oskar Ragnarsson, Gudmundur Johannsson
Feb 13, 2014·Journal of Neuro-oncology·Kelley J MoloneyMarc R Mayberg
Mar 19, 2014·The Journal of Clinical Endocrinology and Metabolism·Paula C L EliasAyrton C Moreira
Jul 1, 2014·European Journal of Endocrinology·Andrea OßwaldMartin Reincke
Dec 30, 2014·The Journal of Clinical Endocrinology and Metabolism·Christina M BerrMartin Reincke
Feb 17, 2015·World Neurosurgery·Tej D AzadLaurence Katznelson
May 26, 2015·Lancet·André LacroixLynnette K Nieman

❮ Previous
Next ❯

Citations

Sep 29, 2020·Frontiers in Bioengineering and Biotechnology·Cheyenne Samson, Ahyeon Koh
Feb 2, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Júlia Vieira Oberger Marques, Cesar Luiz Boguszewski
Mar 23, 2021·Clinical Medicine Insights. Endocrinology and Diabetes·Alice Y ChangKevin Cj Yuen
Jun 21, 2021·Research in Veterinary Science·Alberto Muñoz-PrietoVladimir Mrljak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.