Cushing's syndrome associated with galactorrhea, amenorrhea, and hypothyroidism: a primary hypothalamic disorder

The Journal of Clinical Endocrinology and Metabolism
F G BerlingerJ F Wilber


A 19-year-old woman presented with a unique constellation of endocrinopathies, including Cushing's disease, post-partum galactorrhea, hypothalamic hypothyroidism and hypothalamic amenorrhea. There was no evidence of granulomatous or neoplastic disease in pituitary or hypothalamus. The potential role of excess glucocorticoids and disturbances in normal hypothalamic regulation of anterior pituitary function in the pathophysiology of this syndrome is discussed.


Jan 1, 1981·Journal of Endocrinological Investigation·S RodriguezA Zárate

Related Concepts

Postpartum Amenorrhea
Cushing Syndrome
Endocrine System Diseases
Organum Vasculosum Laminae Terminalis

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