Cushing'S syndrome attributable to topical use of lotrisone.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
S L Weber

Abstract

To emphasize the potentially devastating consequences of topical application of corticosteroids. A case report is presented of a previously healthy 38-year-old woman in whom florid Cushing's syndrome developed after prolonged use of Lotrisone. Four years of continuous topical administration of Lotrisone, a combination antifungal-corticosteroid product, led to the development of Cushing's syndrome. The cream had been applied to less than 10% of the total body surface area without use of occlusive dressings, and the patient had no evidence of liver dysfunction or systemic skin disorder. Laboratory studies revealed an unmeasurable corticotropin level, suppressed or unmeasurable cortisol levels, and suppressed or low-normal 24-hour urine collection values for 17-hydroxy-steroids, 17-ketosteroids, and urinary free cortisol, all of which confirm suppression of the hypothalamic-pituitary-adrenal axis. (1) Betamethasone dipropionate can lead to the development of Cushing's syndrome, even in the absence of enhancing factors. (2) Combination medications can lead to the unintentional use of component agents. (3) Availability of potent corticosteroids as over-the-counter medications allows for inappropriate duration of therapy and inadequa...Continue Reading

References

Jan 30, 1978·JAMA : the Journal of the American Medical Association·T HimathongkamA Sriphrapradang
May 24, 1975·British Medical Journal·R C Staughton, P J August
Mar 6, 1971·The Medical Journal of Australia·J A Keipert, R Kelly
Oct 14, 1972·British Medical Journal·A KellyJ McCluggage
Oct 14, 1972·British Medical Journal·D Oravec, B Lichardus

❮ Previous
Next ❯

Citations

Sep 29, 2011·Integrated Blood Pressure Control·Melpomeni PeppaSotirios A Raptis
Dec 3, 2014·Primary Care·Raghavesh PullalarevuGeoffrey Teehan
May 23, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Michiel W van der LindenRon M C Herings
Apr 27, 2005·Endocrinology and Metabolism Clinics of North America·Rachel L Hopkins, Matthew C Leinung

❮ Previous
Next ❯

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición
Enrique Palomo AtanceJuan Giralt Muiña
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
R B VillanuevaJ L Gabrilove
International Journal of Dermatology
Juan Pablo Castanedo-CazaresBenjamín Moncada
© 2022 Meta ULC. All rights reserved