Cushing's syndrome in a patient with a corticotropin-releasing hormone-producing pheochromocytoma.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
P H EngD H Khoo

Abstract

To present the first case of Cushing's syndrome attributable solely to ectopic production of corticotropin-releasing hormone by a pheochromocytoma. We summarize the clinical features and results of laboratory investigations in a patient with symptoms characteristic of Cushing's syndrome. Although Cushing's syndrome is usually caused by ectopic production of adrenocorticotropic hormone (ACTH), our current patient had clinical and biochemical evidence of hypercortisolism in conjunction with "normal" ACTH levels and nonsuppressible serum and urinary cortisol levels on low-dose and high-dose dexamethasone suppression testing. An abdominal computed tomographic scan revealed a 7.7-cm mass in the left adrenal gland. Light microscopic examination and immunohistochemical staining showed a pheochromocytoma with mild cortical hyperplasia. Immunostaining was positive for corticotropin-releasing hormone but negative for ACTH. To our knowledge, this is the first case of Cushing's syndrome in a patient with pheochromocytoma caused only by ectopic secretion of corticotropin-releasing hormone without accompanying secretion of ACTH.

References

Jan 1, 1992·Archives of Surgery·M F HerreraS L Asa
Nov 1, 1984·The Journal of Clinical Endocrinology and Metabolism·T SudaK Shizume
Dec 1, 1994·Journal of Endocrinological Investigation·M TerzoloA Angeli
Dec 1, 1995·European Journal of Endocrinology·T Mandrup-PoulsenR Bergholdt
Oct 1, 1996·European Journal of Endocrinology·K C LohA H Shlossberg

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Citations

May 31, 2012·Endocrine Pathology·Maria Francesca CassarinoFrancesca Pecori Giraldi
Mar 1, 2012·World Journal of Surgery·James Kirkby-BottBruno Carnaille
Apr 7, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Seda GrigoryanAdina F Turcu
May 2, 2019·Pituitary·Manouchehr NakhjavaniAli A Ghazi
Oct 30, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Farhad ZangenehFereydoun Zangeneh
Feb 6, 2020·BMC Veterinary Research·Sungin LeeWan Hee Kim
Jul 28, 2020·The Journal of Clinical Endocrinology and Metabolism·Patrick F ElliottHenrik Falhammar

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