Cushing's Syndrome in Pediatrics: An Update

Endocrinology and Metabolism Clinics of North America
Maya B LodishConstantine A Stratakis

Abstract

Cushing syndrome (CS) is a multisystem disorder resulting from the prolonged exposure to excess glucocorticoids. In children, CS most commonly results from the exogenous administration of steroids and the typical presentation is height deceleration concomitant with weight gain. Endogenous and ectopic causes are rare. CS in children may be associated with distinct germline and somatic mutations. Clinical practice guidelines are available assist clinicians. Patients should be referred to multidisciplinary centers of excellence with experience in endocrinology and surgery. Early detection and treatment is essential to reduce associated acute and long-term morbidity and potential death.

Citations

Jun 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Michal CohenDov Tiosano
Nov 16, 2019·Journal of Clinical Medicine·Hiroshi Nishioka, Shozo Yamada
Apr 19, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Vania B Brondani, Maria Candida B V Fragoso
Jul 30, 2020·Clinical Endocrinology·Christina TatsiConstantine A Stratakis
Jul 16, 2020·Journal of the Endocrine Society·Christina TatsiConstantine A Stratakis
Jul 11, 2018·Endocrine-related Cancer·Catherine GoudieWilliam D Foulkes
Mar 4, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pediredla KarunakarBiswajit Dubashi
Jun 27, 2019·JIMD Reports·Margaret A StefaterJoseph A Majzoub
Sep 3, 2020·Annals of Pediatric Endocrinology & Metabolism·Kyungchul SongHo-Seong Kim
Jan 28, 2021·Journal of Pediatric Surgery·Gregory A MetzgerPeter C Minneci
Feb 2, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Júlia Vieira Oberger Marques, Cesar Luiz Boguszewski
Jun 24, 2020·Seminars in Pediatric Surgery·Zachary J Kastenberg, Eric R Scaife
Mar 25, 2021·The New England Journal of Medicine·Kristian R OlsonZehra Ordulu
Apr 6, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Monica Livia Gheorghiu
May 1, 2021·Journal of the Endocrine Society·Grethe Å UelandPaal Methlie
Jun 6, 2021·The Journal of Allergy and Clinical Immunology·SuJin HwangSergio D Rosenzweig
Jul 29, 2021·The Journal of Clinical Endocrinology and Metabolism·Alise A van HeerwaardeDaniëlle C M van der Kaay
Sep 6, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Karen S TuanoJavier Chinen
Nov 14, 2020·Current Pharmaceutical Design·Eleni P KotanidouAssimina Galli-Tsinopoulou

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