Cut-off points of homeostasis model assessment of insulin resistance, beta-cell function, and fasting serum insulin to identify future type 2 diabetes: Tehran Lipid and Glucose Study

Acta Diabetologica
Asghar GhasemiFarzad Hadaegh

Abstract

To determine cut-off points of homeostasis model assessment of insulin resistance (HOMA-IR), β-cell function (HOMA-B), insulin sensitivity (HOMA-S), and fasting insulin for identifying the subjects with type 2 diabetes mellitus (T2DM) in Iranian adults using data from a prospective population-based study. From participants of Tehran Lipid and Glucose Study, 4942 Iranian subjects, aged 20-86 years, were followed for incident T2DM. Fasting serum insulin was determined by the electrochemiluminescence immunoasaay. The associations between HOMA-IR, HOMA-B, HOMA-S, and fasting insulin and incident T2DM were evaluated using Cox proportional hazards models. The receiver operator characteristic curve analysis was used to determine the cut-off points of HOMA-IR, HOMA-B, HOMA-S, and fasting insulin. After 9.2 year follow-up, 346 (7.0 %) incident cases of T2DM were identified; the risk-factor-adjusted hazard ratios for HOMA1-IR, HOMA2-IR, HOMA1-B, HOMA2-B, HOMA1-S, HOMA2-S, and insulin were 1.15, 1.70, 0.732, 0.997, 0.974, 0.986, and 1.01 in women and 1.37, 1.67, 0.588, 0.993, 0.986, 0.991, and 1.06 in men, respectively (all p < 0.05 except for HOMA2-B in women). Optimal cut-off points for HOMA1-IR, HOMA2-IR, HOMA1-B, HOMA2-B, HOMA1-S, HOM...Continue Reading

References

Jan 1, 1993·Medicine and Science in Sports and Exercise·B E AinsworthA S Leon
Feb 28, 2004·Diabetes Care·Charlotte GlümerUNKNOWN inter99 study
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Jan 18, 2006·American Journal of Epidemiology·Neil J Perkins, Enrique F Schisterman
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Sep 29, 2007·Diabetes Care·Edward J Boyko, Christine Chen Jensen
Oct 25, 2007·American Journal of Physiology. Endocrinology and Metabolism·Ranganath MuniyappaMichael J Quon
May 26, 2009·Arquivos brasileiros de endocrinologia e metabologia·Bruno GelonezeUNKNOWN BRAMS Investigators
Jul 23, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jeong Gyu LeeJi Eun Kim
Oct 28, 2009·Obesity·John M Evans
May 25, 2010·Journal of Nutritional Science and Vitaminology·Chiyoko UsuiMitsuru Higuchi
Oct 27, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·V PrimeauR Rabasa-Lhoret
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Gerald Reaven
May 28, 2011·Acta Diabetologica·Mohammadreza BozorgmaneshFereidoun Azizi
Nov 25, 2011·BMC Medical Research Methodology·Anwar BoraiGordon Ferns
Dec 17, 2011·The Journal of Clinical Endocrinology and Metabolism·Carlos LorenzoSteven M Haffner
Jan 18, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·M KatoUNKNOWN Omiya MA Cohort Study Group
Jul 23, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Stanisław NiemczykJoanna Matuszkiewicz-Rowińska
Nov 20, 2013·Indian Journal of Endocrinology and Metabolism·Romesh Khardori
Jan 1, 2014·Progress in Molecular Biology and Translational Science·Lyudmila I Rachek
Mar 26, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J A BellM Hamer
Apr 2, 2014·Acta Diabetologica·Federico SoriguerGemma Rojo-Martínez
Oct 7, 2011·Journal of Diabetes Investigation·Chizumi YamadaEiko Takahashi
Aug 19, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·A DerakhshanF Hadaegh

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Citations

Nov 26, 2015·International Journal of Food Sciences and Nutrition·Zahra BahadoranFereidoun Azizi
Mar 10, 2016·Diabetes & Metabolic Syndrome·Daliparthy D PratyushSurya K Singh
Feb 9, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Parvin MirmiranFereidoun Azizi
Jun 20, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuya SekoYoshito Itoh
Sep 30, 2017·Nutritional Neuroscience·Deborah TeixeiraRenata Padilha Guedes
Nov 17, 2017·Journal of Health, Population, and Nutrition·Abdel Hamid El BilbeisiKurosh Djafarian
Apr 17, 2018·The Journal of Clinical Endocrinology and Metabolism·Barbara E StähliGregory G Schwartz
Sep 29, 2017·Stroke; a Journal of Cerebral Circulation·Yuesong PanYilong Wang
Dec 22, 2016·The Journal of Clinical Endocrinology and Metabolism·Charlotte VerrokenBruno Lapauw
Sep 19, 2019·Journal of the Endocrine Society·Dylan D ThomasCaroline M Apovian
Jul 12, 2017·Menopause : the Journal of the North American Menopause Society·Margarita MashaviMarina Shargorodsky
Mar 3, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Rasintra SiriwatSally Ibrahim
Jun 23, 2020·Maternal & Child Nutrition·Szimonetta EitmannErika Pétervári
Feb 6, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Maryam TohidiAsghar Ghasemi
Apr 3, 2019·International Journal of Environmental Research and Public Health·Dorota ŁojkoAleksandra Suwalska
Jul 8, 2020·Scientific Reports·Carolina B LobatoMariana P Monteiro
Jun 10, 2018·Diabetes & Metabolism Journal·Jong Ha BaekJaehoon Jung
Jan 17, 2019·Journal of Diabetes Research·Rodrigo M Carrillo-Larco Cronicas Cohort Study Group
Apr 2, 2020·Journal of the Endocrine Society·Riku KlénPirjo Nuutila
Apr 11, 2018·Schizophrenia Bulletin·Benjamin Ian PerryGolam Khandaker
Jan 12, 2021·Frontiers in Endocrinology·Carolina B LobatoMariana P Monteiro
Sep 8, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sevda GheibiAsghar Ghasemi
Sep 6, 2020·Medicine and Science in Sports and Exercise·Felipe Mattioni MaturanaAndreas M NIEß
Apr 6, 2021·Topics in Spinal Cord Injury Rehabilitation·Phillip S GordonDavid R Gater

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