Cut-off value of FEV1/FEV6 to determine airflow limitation using handheld spirometry in subjects with risk of chronic obstructive pulmonary disease.

The Korean Journal of Internal Medicine
Yong Il HwangChang Youl Lee

Abstract

Postbronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) less than 0.7 using spirometry is the golden standard to diagnose airf low limitation of chronic obstructive pulmonary disease (COPD). Recently, measuring FEV6 has been suggested as an alternative to measure FVC. Studies about the cut-off value for FEV1/FEV6 to diagnose airflow limitation have shown variable results, with values between 0.7 and 0.8. The purpose of this study was to determine the best cut-off value of FEV1/FEV6 to detect airflow limitation using handheld spirometry. We recruited subjects over 40 years of age with smoking history over 10 pack-years. Participants underwent measurements with both handheld spirometry and conventional spirometry. We calculated the sensitivity and specificity of the value of FEV1/FEV6 using receiver-operating characteristic (ROC) curve analysis to obtain the diagnostic accuracy of handheld spirometry to detect airflow limitation. A total of 290 subjects were enrolled. Their mean age and smoking amount were 63.1 years and 31.6 pack-years, respectively. According to our ROC curve analysis, when FEV1/FEV6 ratio was 73%, sensitivity and specificity were the maximum and the area under the ROC curve w...Continue Reading

References

Feb 16, 2000·Chest·S D SullivanT A Lee
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·M P SwanneyR O Crapo
Jul 16, 2002·Respiratory Medicine·R L EnrightW C Bailey
Nov 30, 2006·PLoS Medicine·Colin D Mathers, Dejan Loncar
Feb 24, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kwang H YooSung K Han
Apr 7, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Gregory D SalinasJill A Foster
Sep 1, 2016·International Journal of Chronic Obstructive Pulmonary Disease·Kyung Soo ChungJoo Han Song
Mar 8, 2017·American Journal of Respiratory and Critical Care Medicine·Shawn D AaronUNKNOWN Canadian Respiratory Research Network
Aug 24, 2017·International Journal of Chronic Obstructive Pulmonary Disease·Peter KjeldgaardCharlotte Suppli Ulrik
Jan 1, 2018·Pulmonary Pharmacology & Therapeutics·Jaya MuneswaraoMohamed Azmi Ahmad Hassali

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