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Cut site selection by the two nuclease domains of the Cas9 RNA-guided endonuclease

The Journal of Biological Chemistry

Mar 19, 2014

Hongfan ChenScott Bailey

Abstract

Cas9, the RNA-guided DNA endonuclease from the CRISPR-Cas (clustered regularly interspaced short palindromic repeat-CRISPR-associated) system, has been adapted for genome editing and gene regulation in multiple model organisms. Here we characterize a Cas9 ortholog from Streptococcus the...read more

Mentioned in this Paper

Deoxyribonuclease I
Bacterial Proteins
Endonuclease
Tertiary Protein Structure
Streptococcus thermophilus
Cytokinesis of the Fertilized Ovum
Nuclease
Protein Domain
Cytokinesis
Clustered Regularly Interspaced Short Palindromic Repeats
165
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Cut site selection by the two nuclease domains of the Cas9 RNA-guided endonuclease

The Journal of Biological Chemistry

Mar 19, 2014

Hongfan ChenScott Bailey

PMID: 24634220

DOI: 10.1074/jbc.m113.539726

Abstract

Cas9, the RNA-guided DNA endonuclease from the CRISPR-Cas (clustered regularly interspaced short palindromic repeat-CRISPR-associated) system, has been adapted for genome editing and gene regulation in multiple model organisms. Here we characterize a Cas9 ortholog from Streptococcus the...read more

Mentioned in this Paper

Deoxyribonuclease I
Bacterial Proteins
Endonuclease
Tertiary Protein Structure
Streptococcus thermophilus
Cytokinesis of the Fertilized Ovum
Nuclease
Protein Domain
Cytokinesis
Clustered Regularly Interspaced Short Palindromic Repeats
165

Similar Papers Found In These Feeds

CRISPR for Genome Editing

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

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