Cutaneous adverse effects during ipilimumab treatment for metastatic melanoma: a prospective study

European Journal of Dermatology : EJD
Emi DikaAnnalisa Patrizi

Abstract

Ipilimumab is an immunomodulatory antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which is administered to patients with advanced melanoma, with a proven positive effect on overall survival. The cutaneous adverse effects (AEs) of ipilimumab are relatively frequent, although described as usually mild and rarely life threatening. To describe a three-year experience of a single institute in detecting and managing cutaneous AEs. A cohort of patients (n = 41) treated with ipilimumab (3 mg/kg/three weeks) for metastatic melanoma, from 2013 to 2016, was investigated for adverse cutaneous events. On dermatological evaluation, 34.1% of the patients in our series developed cutaneous AEs: rash (7.3%; n = 3), folliculitis (7.3%; n = 3), mucositis (2.4%; n = 1), rosacea (2.4%; n = 1), eczema (2.4%; n = 1), acneiform eruption (2.4%; n = 1), syringometaplasia mucinosa (2.4%; n = 1), Stevens-Johnson syndrome (2.4%; n = 1), and vitiligo (4.9%; n = 2). These were all Grade 1 and 2 AEs, except for the case of Stevens-Johnson syndrome (Grade 4). On a patient-reported scale, 4.9% (n = 2) and 9.8% (n = 4) of the patients complained of severe xerosis and pruritus, respectively. Ipilimumab was relatively well tolerated ...Continue Reading

Citations

Dec 20, 2017·American Journal of Clinical Dermatology·Vincent Sibaud
Apr 14, 2018·Journal of Immunology Research·Chun-Bing ChenWen-Hung Chung
Mar 10, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Macartney WelbornAnisha B Patel
Aug 31, 2019·Dermatologic Clinics·Leonora BomarChristine Ahn
Mar 22, 2020·Clinics in Dermatology·Emily L ColemanJonathan S Leventhal
Dec 21, 2020·Clinics in Dermatology·Neeta MalviyaAllireza Alloo
Apr 4, 2021·Journal of Clinical Medicine·Emi DikaSimone Ribero
Jun 4, 2021·Molecular Oncology·Barbara MonticoElisabetta Fratta
Jul 25, 2021·Journal of Clinical Medicine·Lorenza BurziSimone Ribero
Aug 2, 2021·Journal of the American Academy of Dermatology·Henry T QuachAnna K Dewan
Aug 7, 2021·PloS One·Náthali Felícia Mineiro Dos Santos GarrettChristiane Inocêncio Vasques
Nov 18, 2021·Immunotherapy·Cathal O'ConnorCynthia Heffron

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