Cutaneous and inflammatory response to long-term percutaneous implants of sphere-templated porous/solid poly(HEMA) and silicone in mice.

Journal of Biomedical Materials Research. Part a
Philip FleckmanJohn E Olerud

Abstract

This study investigates mouse cutaneous responses to long-term percutaneously implanted rods surrounded by sphere-templated porous biomaterials engineered to mimic medical devices surrounded by a porous cuff. We hypothesized that keratinocytes would migrate through the pores and stop, permigrate, or marsupialize along the porous/solid interface. Porous/solid-core poly(2-hydroxyethyl methacrylate) [poly(HEMA)] and silicone rods were implanted in mice for 14 days, and for 1, 3, and 6 months. Implants with surrounding tissue were analyzed (immuno)histochemically by light microscopy. Poly(HEMA)/skin implants yielded better morphologic data than silicone implants. Keratinocytes at the poly(HEMA) interface migrated in two different directions. "Ventral" keratinocytes contiguous with the dermal-epidermal junction migrated into the outermost pores, forming an integrated collar surrounding the rods. "Dorsal" keratinocytes appearing to emanate from the differentiated epithelial layer, extended upward along and into the exterior portion of the rod, forming an integrated sheath. Leukocytes persisted in poly(HEMA) and silicone pores for the duration of the study. Vascular and collagen networks within the poly(HEMA) pores matured as a functi...Continue Reading

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Citations

Dec 18, 2013·Tissue Engineering. Part B, Reviews·Carlos Filipe C JoãoJoão Paulo Borges
Jul 16, 2013·Journal of Biomedical Materials Research. Part a·Brian J McMahonRebecca L Carrier
Aug 3, 2014·Biomaterials·Wenqi TengBuddy D Ratner
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Jan 29, 2017·Journal of Biomedical Materials Research. Part a·Daniel HachimBryan N Brown
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Sep 30, 2017·Advanced Healthcare Materials·Mohamed-Nur AbdallahFaleh Tamimi
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Oct 1, 2019·Clinical and Translational Science·Richard M H LeePeng Tee Khaw
Feb 2, 2021·Science Advances·Dianyu DongShaoyi Jiang
Jul 13, 2015·ACS Biomaterials Science & Engineering·Anna GalperinBuddy D Ratner
Sep 12, 2016·ACS Biomaterials Science & Engineering·Pitirat PholpabuChristopher J Bettinger

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