PMID: 9638275Jun 25, 1998Paper

Cutaneous and subcutaneous granulomata formation in mice immunized and challenged with third-stage infective hookworm (Ancylostoma caninum) larvae

Acta Tropica
Y YangPeter J Hotez

Abstract

To determine the inflammatory and immunological mechanisms associated with live third-stage (L3) hookworm larval vaccines, mice were immunized either subcutaneously or orally with three doses of 500 L3 of Ancylostoma caninum at 2-week intervals, and then challenged percutaneously (via abdominal skin) with 500 L3. Non-immunized mice served as negative controls. Skin was excised from post-challenge mice at intervals between 6 h and 28 days, and then examined by light microscopy. In non-immunized mice the L3 exhibited no structural damage and infiltrating inflammatory cells were absent from the surrounding tissues. There were no changes in the cutaneous architecture. In contrast, skin recovered from the immunized mice was edematous and exhibited marked inflammatory changes with resultant destruction of the challenge L3. At 6 h post-challenge the L3 exhibited cuticular swelling and damage; the surrounding tissue was infiltrated by polymorphonuclear inflammatory cells. By 24 h granulomata in the dermis, subcutaneous tissues and underlying abdominal muscles were first observed surrounding dead L3. The number of granulomata peaked at 72 h, with the majority distributed in the subcutaneous tissues. Plasma cells predominated in the earl...Continue Reading

References

Jan 1, 1992·Memórias do Instituto Oswaldo Cruz·R A Wilson
May 1, 1993·Parasitology·R J QuinnellD I Pritchard
Sep 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·M AlbonicoL Savioli
Oct 1, 1996·Pediatric Research·P J HotezS H Xiao
Jul 1, 1997·Emerging Infectious Diseases·P J HotezG M Davis

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Citations

Dec 3, 1999·Immunological Reviews·P J HotezR A Koski
Apr 23, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Lars KocherscheidtPeter T Soboslay

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