Cutaneous elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin

The British Journal of Dermatology
A GeusauM McLachlan

Abstract

After exposure, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is excreted via the faeces, breast milk and epidermal lipids. To determine to what extent TCDD is eliminated via the skin and to evaluate whethe cutaneous elimination can be accelerated by the application of petrolatum. In two patients severely intoxicated with TCDD, material obtained from the skin surface and, in one patient, cerumen and the content of epithelial cysts, was analysed for TCDD. The TCDD concentration in the initial blood sample taken was 144 000 pg g(-1) blood fa in patient 1, and 26 000 pg g(-1) blood fat in patient 2. Six months later, when the skin tests were performed, the blood TCDD levels had decreased to 80 900 and 16 100 pg g(-1) blood fat, respectively. In the two samples of pooled cyst contents from patient 1, TCDD levels of 34 400 an 18 600 pg g(-1) fat were found. A cerumen sample contained TCDD at 20 500 pg g(-1) fat. In the material collected from the skin surface we observed a linear increase of the amount of TCD measured per test field with time, indicating a continuous elimination of TCDD via the skin. Th daily amount of TCDD eliminated via the skin was 1.51 pg cm(-2) in patient 1 and 0.57 pg cm(-2) in patient 2. Application of petrolatu...Continue Reading

References

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Citations

Mar 29, 2014·Ageing Research Reviews·Márcio LorenciniHoward I Maibach
Aug 11, 2012·Bioscience, Biotechnology, and Biochemistry·Noriyuki KohdaTakao Saito
May 12, 2012·Journal of Dermatological Science·Leonard M MilstoneJing Zhou
Jul 27, 2015·Journal of the American Academy of Dermatology·Andrew T PattersonDirk M Elston
Jun 10, 2015·Environmental Toxicology and Pharmacology·Joanna Rosińczuk, Ireneusz Całkosiński
Feb 1, 2006·Environmental Research·Arnold SchecterJohn D Constable
Nov 19, 2013·Toxicology Letters·Olivier Sorg
Mar 25, 2005·The British Journal of Dermatology·A BaccarelliM T Landi

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