Cutaneous events during anti-TNF alpha therapy: a prospective observational study of 41 cases

Annales de dermatologie et de vénéréologie
N BonnetP Berbis

Abstract

The cutaneous adverse effects of TNFalpha inhibitors and their potential implication in the onset of associated dermatoses remain poorly understood. To describe the different clinical dermatological situations seen in patients treated with TNFalpha inhibitors. We conducted a prospective, observational study of patients followed at the Dermatology Department of the CHU Nord university teaching hospital of Marseilles. All patients, referred by various departments, were treated with TNFalpha inhibitors and presented cutaneous events. Forty-one patients were included in the study. Various cutaneous manifestations were observed, including: 15 psoriatic rashes, six skin infections, three eczema rashes, three cases of lupic syndrome, two anaphylactic reactions to infusion and two cutaneous drug reactions. An original case of parapsoriasis was observed. Cutaneous tumors are rarely described. This study confirms the multiple clinical dermatological situations observed in patients treated with TNFalpha inhibitors and illustrates the need for good coordination between dermatologists and other specialists in order to ensure optimal management of this population.

References

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Citations

Mar 15, 2014·Anais Brasileiros De Dermatologia·Clarissa Luiza Dalla Bernardina Carvalho, Luciena Cegatto Martins Ortigosa
Aug 30, 2013·Expert Opinion on Drug Safety·Hong Yang, Arthur Kavanaugh
Jun 14, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·L Méry-BossardE Toussirot
Jul 8, 2015·The British Journal of Dermatology·K C WebbI C Le Poole
Jun 10, 2015·Revista brasileira de reumatologia·Licia Maria Henrique da MotaLuis Eduardo Coelho Andrade

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