Cutaneous fungal microbiome: Malassezia yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trial

Dermato-endocrinology
C S L KamamotoE Bagatin

Abstract

Malassezia spp in skin microbiome scalp has been implicated in seborrheic dermatitis pathogenesis. Thus, treatment based in antifungal combined to topical keratolitic agents have been indicated as well as oral isotretinoin as it reduces the sebum production, glandular's size and possesses anti-inflammatory properties. This randomized, comparative and therapeutic trial aimed toper form the genotypic identification of Malassezia species before and after low-dose oral isotretinoin or topical antifungal treatments for moderate to severe seborrhea and/or seborrheic dermatitis on scalp. Scales and sebum of the scalp were seeded in the middle of modified Dixon and incubated at 32°C. For genotypic identification polymerase chain reaction primers for the ITS and D1/D2 ribossomal DNA were used and followed by samples sequencing. The procedure was conducted before and after therapeutic and randomized intervention for moderate to severe seborrhea/seborrheic dermatitis on the scalp, including oral isotretinoin, 10 mg, every other day and anti-seborrheic shampoo (piroctone olamine), over six months. The M. globosa and M. restricta were the most frequent species isolated on the scalp before and after both treatments. Other non-Malassezia spec...Continue Reading

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Citations

Jul 31, 2019·BioMed Research International·Poonkiat SuchonwanitKanchana Leerunyakul
Sep 5, 2019·Journal of Clinical Immunology·Nuria B ZurroAntonio Condino-Neto
Oct 1, 2020·BMC Dermatology·Mariusz DylągLukasz Kozubowski
Dec 2, 2020·The Journal of Allergy and Clinical Immunology·Raquel Castillo-GonzálezFrancisco Sánchez-Madrid

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT01139749

Software Mentioned

Sequencher®
SPSS

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