Cutaneous granulomatous reaction to injectable hyaluronic acid gel

The British Journal of Dermatology
M GhislanzoniE Alessi

Abstract

Injectable hyaluronic acid (HA) derivatives are the most used reabsorbable dermal fillers for soft tissue augmentation today and their utilization is considered safe. We report a cutaneous granulomatous reaction that developed in a woman 5 weeks after the first treatment with a nonanimal HA derivative for the correction of facial wrinkling. We describe the clinicopathological findings and course of the cutaneous reaction. The adverse reaction showed clinical and histopathological characteristics comparable to the few previously reported cases. All cutaneous lesions spontaneously disappeared without scars within 3 months. We conclude that even nonanimal injectable HA derivatives can be associated with delayed granulomatous reactions. The patient should be informed of this potential long-term complication.

References

Dec 29, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·F DurantiM L Rosati
Feb 26, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·J R Lupton, T S Alster
Oct 20, 2000·Plastic and Reconstructive Surgery·R ShafirE Gur
Feb 24, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·P Micheels
Oct 16, 2001·Dermatologic Clinics·A W Klein
Jun 26, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Paul M FriedmanRoy G Geronemus
Jun 18, 2003·Archives of Dermatology·Franco RongiolettiAlfredo Rebora
Dec 3, 2003·Aesthetic Plastic Surgery·Gottfried LemperleUlrich Charrier

❮ Previous
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Citations

Nov 1, 2011·Aesthetic Plastic Surgery·Hande AltintasOzcan Cakmak
Oct 11, 2011·Head and Neck Pathology·Shokoufeh Shahrabi FarahaniSook-Bin Woo
Sep 17, 2013·American Journal of Clinical Dermatology·Jennifer A LedonKeyvan Nouri
Nov 5, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Berit SperlingBerthold Rzany
Sep 1, 2007·Journal of Clinical Pathology·Mubarak Al-ShraimWilliam Geddie
Nov 1, 2012·Journal of Cutaneous and Aesthetic Surgery·Enis Rauf Coskuner, Halil Ibrahim Canter
Dec 22, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Lise Christensen
Dec 22, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Robert G HamiltonN Franklin Adkinson
Apr 22, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·T ZilliR Miralbell
Dec 10, 2013·Clinics in Dermatology·Suhan Günaştı, Varol L Aksungur
Oct 2, 2012·Dermatologic Clinics·Luis RequenaHeinz Kutzner
Oct 22, 2011·Clinics in Dermatology·Jason Emer, Heidi Waldorf
Dec 21, 2010·Journal of the American Academy of Dermatology·Luis RequenaLorenzo Cerroni
May 25, 2010·Cirugía española·Carlos Fortea-SanchisJosé Luis Salvador-Sanchis
Nov 27, 2009·International Journal of Radiation Oncology, Biology, Physics·Robert C SusilDanny Song
Dec 7, 2007·La Revue de médecine interne·D Vital DurandH Rousset
Oct 29, 2008·Clinical and Experimental Dermatology·J M WallerS W Dyson
Jun 21, 2006·Dermatologic Therapy·Arnold William Klein
Oct 30, 2013·International Journal of Dermatology·Emanuele CozzaniAurora Parodi
Sep 3, 2013·Journal of Cosmetic Dermatology·Ioannis E LiapakisEleftherios I Paschalis
Jul 6, 2015·Dermatologic Clinics·Ana M Molina-Ruiz, Luis Requena
Oct 30, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·F RongiolettiS Fraitag
Jun 9, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ruchielli Loureiro BorghettiMaria Antonia Zancanaro de Figueiredo
Oct 12, 2014·International Journal of Radiation Oncology, Biology, Physics·Gary MokThomas Zilli
Jul 21, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Jose Maria Sanchis-BielsaInmaculada Salvador
Jun 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ilker S Bayer
Oct 28, 2020·American Journal of Clinical Dermatology·Nidhi ShahRoni P Dodiuk-Gad
Jan 3, 2021·Tropical Animal Health and Production·Mohamed Tharwat, Abdulla Al-Hawas
May 21, 2014·Ophthalmic Plastic and Reconstructive Surgery·Frederick A JakobiecFrancis C Sutula
Jun 4, 2008·Ophthalmic Plastic and Reconstructive Surgery·Bryan SiresPegi Whitehouse
Mar 26, 2009·The American Journal of Dermatopathology·Cesare MassoneLorenzo Cerroni
Jan 30, 2010·The American Journal of Dermatopathology·Florencia AnatelliJeoffry Brennick
Mar 30, 2013·JAMA Facial Plastic Surgery·Steven M Daines, Edwin F Williams
Dec 20, 2012·The American Journal of Dermatopathology·Ana M Molina-RuizLuis Requena
May 26, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Omer IbrahimJeffrey S Dover
Dec 15, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ofir ArtziMarina Landau
May 8, 2015·The Journal of Craniofacial Surgery·Marcos Martins CuriMaria Beatriz Benini
Mar 17, 2007·The Journal of Dermatological Treatment·Federico BardazziMichela Tabanelli
May 6, 2008·Annales de dermatologie et de vénéréologie·F Rongioletti
Jan 19, 2008·Journal of Cutaneous Pathology·Ophelia Entsir DadzieJag Bhawan
Jul 3, 2008·Plastic and Reconstructive Surgery·Fabio M AbenavoliRoberto Corelli
Jun 2, 2009·Plastic and Reconstructive Surgery·Gottfried LemperleDavid M Duffy
Jun 2, 2009·Plastic and Reconstructive Surgery·Gottfried Lemperle, Nelly Gauthier-Hazan
Jul 29, 2011·Science Translational Medicine·Alexander T HillelJennifer H Elisseeff

❮ Previous
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