PMID: 9449487Feb 4, 1998Paper

Cutaneous histopathology of Rocky Mountain spotted fever

Journal of Cutaneous Pathology
G F KaoJ S Dumler

Abstract

The dermatologic diagnosis of Rocky Mountain spotted fever (RMSF) is often presumptive; the clinical presentation includes skin rash and febrile illness with or without a clear history of tick bite. The characteristic cutaneous manifestations include a generalized skin eruption with purpuric, blanching or non-blanching macules and papules usually involving the extremities. Although skin biopsies are often performed to confirm the diagnosis, the spectrum of cutaneous histopathology in RMSF has not been well described. We studied a series of 26 cases of RMSF, of which 10 were surgical specimens and 16 were autopsies. The microscopic changes were correlated with the duration of illness. The main histopathologic feature was lymphohistiocytic capillaritis and venulitis with extravasation of erythrocytes, edema, predominantly perivascular and some interstitial infiltrate. Leukocytoclastic vasculitis (LCV) with neutrophilic infiltrate and nuclear dust was seen in 11 of 15 (73%) specimens from involved skin. These lesions with LCV also showed notable epidermal change including basal layer vacuolar degeneration with mild dermoepidermal interface lymphocytic exocytosis. Six lesions with LCV displayed focal fibrin thrombi and capillary wa...Continue Reading

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Citations

Oct 28, 2003·The American Journal of Pathology·Wun-Ju ShiehUNKNOWN Anthrax Bioterrorism Investigation Team
Oct 3, 2002·International Journal of Dermatology·Y Isabel Zhu, Matthew J Stiller
May 16, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amy M DenisonChristopher D Paddock
Apr 2, 2005·Clinics in Dermatology·Marcia Ramos-e-Silva, Ana Libia Cardozo Pereira
Aug 25, 2018·Tropical Doctor·Peter Cv DincyPrakash John Aj
Apr 19, 2018·Biomédica : revista del Instituto Nacional de Salud·Jesús Delgado-De la MoraGerardo Álvarez-Hernández
Apr 29, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·N L LaczR Kapila
Jul 14, 2005·Medical Mycology·Pranab K MukherjeeMahmoud A Ghannoum
Feb 24, 2015·The American Journal of Dermatopathology·Ana María Molina-RuizLuis Requena
Aug 8, 2001·Clinical and Experimental Dermatology·M AkhyaniZ S Naraghi
Nov 22, 2019·Veterinary Dermatology·Elizabeth A MauldinJulie A Yager
Oct 9, 2009·Autoimmunity·Merav LidarYehuda Shoenfeld
Sep 10, 2003·Journal of the American Academy of Dermatology·Daniel E McGinley-Smith, Sandy S Tsao
Nov 20, 2021·The American Journal of Dermatopathology·Shauna RiceLeslie Robinson-Bostom

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