Cutaneous Human Papillomaviruses and Squamous Cell Carcinoma of the Skin: Nested Case-Control Study

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Helena FaustJoakim Dillner

Abstract

Cutaneous human papillomavirus (HPV) types have been associated with non-melanoma skin cancer (NMSC), including a previous nested case-control study using HPV serology with bacterially derived fusion proteins with the major HPV capsid protein L1 (GST-L1). However, HPV serology using conformationally intact pseudovirions has been shown to correlate better with natural infection. Prospective studies using a more valid marker of infection are therefore warranted. Cancer registry follow-up of large Nordic biobanks identified prediagnostic serum samples from 633 subjects who later developed SCC, 1,990 subjects who developed basal cell carcinoma (BCC). The samples from cases and matched controls were tested for IgG to pseudovirions to 16 different HPV types (3, 5, 6, 11, 15: , 16, 18, 31, 32, 33, 38: , 45, 52, 58, 68, and 76: ) and two polyomaviruses (MCPyV and JCPyV). Baseline seropositivity was not associated with SCC risk, and there were only weak associations with BCC risk [HPV-5 (OR, 1.1; 95% confidence interval [CI], 1.0-1.3), HPV-15 (OR, 1.2; 95% CI, 1.0-1.4), HPV-38 (OR, 1.2; 95% CI, 1.0-1.3), and MCPyV (OR, 1.1; 95% CI, 1.0-1.3)]. Acquisition of HPV-5 seropositivity during follow-up was associated with SCC risk (OR, 3.2; 95%...Continue Reading

References

Mar 14, 2000·Seminars in Cancer Biology·J Dillner
Nov 7, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mariet C W FeltkampJan Ter Schegget
Feb 26, 2010·The Journal of General Virology·Helena FaustJoakim Dillner
Mar 16, 2012·American Journal of Epidemiology·Kristin AnderssonJoakim Dillner
Nov 13, 2014·International Journal of Cancer. Journal International Du Cancer·L Sara Arroyo MührJoakim Dillner

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Citations

Oct 13, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jan N Bouwes BavinckUNKNOWN EPI-HPV-UV-CA group
Sep 28, 2018·The Journal of Infectious Diseases·Dana E RollisonMassimo Tommasino
May 27, 2017·The Journal of Infectious Diseases·Shalaka S HamprasMassimo Tommasino
May 28, 2019·Frontiers in Oncology·Tarik Gheit
Jul 18, 2020·The American Journal of Dermatopathology·Paranita FerronikaIrianiwati Widodo
Jan 24, 2019·Acta Cytologica·Laura SicheroMassimo Tommasino

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