Cutaneous immunopathology of long-standing complex regional pain syndrome

European Journal of Pain : EJP
S OsborneAndreas Goebel

Abstract

Both increased mast cells numbers and raised immune mediator concentrations indicate immune activation in the affected skin of patients with early complex regional pain syndrome (CRPS), but little is known about regional immune cell involvement in late-stage CRPS. The aim of the current study was to determine skin immune cell populations in long-standing CRPS. Using 6-mm skin punch biopsies from CRPS-affected and non-affected tissues, and a combination of chemical and immunofluorescence staining, we examined the density and function of key cell populations including mast cells, epidermal Langerhans cells (LCs) and tissue resident T-cells. We found no significant differences in either overall immune cell infiltrates, or mast cell density between CRPS-affected and non-affected sub-epidermal tissue sections, contrasting recent findings in early CRPS by other groups. However, CD1a(+) LC densities in the epidermal layer were significantly decreased in affected compared to non-affected CRPS limbs (p < 0.01). T-cell clones isolated from CRPS-affected sub-epidermal tissues displayed a trend towards increased IL-13 production in ELISPOT assays when compared to T-cells isolated from non-affected areas, suggesting a Th2 bias. Immune cell ...Continue Reading

References

Sep 1, 1996·Journal of Neurocytology·S T HsiehJ W Griffin
Jun 2, 1998·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·J S CalderR M McAllister
Mar 22, 2002·Nature Reviews. Immunology·Foo Y Liew
Apr 5, 2002·Mediators of Inflammation·Frank J P M HuygenFreek J Zijlstra
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristina SeiffertRichard D Granstein
Feb 18, 2003·The British Journal of Dermatology·A WeberM Maurer
Mar 8, 2003·Archives of Dermatological Research·Anne Louise OaklanderPeter R Mouton
Jun 6, 2003·The Journal of Allergy and Clinical Immunology·Dean J NaisbittB Kevin Park
Mar 17, 2004·Immunology Letters·Frank J P M HuygenFreek J Zijlstra
Mar 26, 2004·The Journal of Pain : Official Journal of the American Pain Society·Gabriel TanBilal F Shanti
Mar 4, 2005·The Journal of Pharmacology and Experimental Therapeutics·Dean J NaisbittB Kevin Park
Sep 13, 2005·Cytokine·C E M GriffithsI Kimber
Jan 28, 2006·The Journal of Investigative Dermatology·Akiko NishibuAkira Takashima
Dec 29, 2006·Annals of the New York Academy of Sciences·Kristina Seiffert, Richard D Granstein
May 15, 2007·The Journal of Investigative Dermatology·Wanhong DingRichard D Granstein
Jul 6, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·R Norman HardenPeter R Wilson
Nov 9, 2007·The Journal of Investigative Dermatology·C Elise KleynChristopher E M Griffiths
Feb 2, 2008·Neuroimmunomodulation·Ines KaufmannManfred Thiel
Apr 22, 2008·Neuroscience Letters·Frank Birklein, Martin Schmelz
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wanhong DingRichard D Granstein
Nov 13, 2008·Cellular and Molecular Life Sciences : CMLS·K MutyambiziR L Edelson
Mar 17, 2010·Immunology and Cell Biology·Sandrine HenriBernard Malissen
Mar 17, 2010·Immunology and Cell Biology·Botond Z Igyarto, Daniel H Kaplan
Mar 31, 2010·Immunology and Cell Biology·Björn E Clausen, Junda M Kel
Mar 1, 2012·Pain·Jordi Casanova-MollaJosep Valls-Solé
Jul 21, 2012·Nature Immunology·William R Heath, Scott N Mueller
Jun 25, 2013·Pain Practice : the Official Journal of World Institute of Pain·Thomas Birley, Andreas Goebel
Jan 28, 2014·The Journal of Pain : Official Journal of the American Pain Society·Frank BirkleinWade S Kingery

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Citations

Feb 18, 2016·Autoimmunity Reviews·Andreas Goebel
Mar 17, 2018·Nature Reviews. Neurology·Frank BirkleinClaudia Sommer
Aug 21, 2018·Molecular Pain·J David ClarkWade S Kingery
Aug 15, 2017·Expert Review of Proteomics·Simone KönigFrank Birklein
Aug 1, 2019·Molecular Diagnosis & Therapy·Krishna D BharwaniFrank J P M Huygen
Jun 22, 2017·Mediators of Inflammation·Krishna D BharwaniFrank J P M Huygen
Nov 14, 2020·Biology of Sex Differences·Katja Linher-MelvilleGurmit Singh
Jan 26, 2021·Journal of Translational Autoimmunity·Christopher ChangM Eric Gershwin
Apr 1, 2021·Molecular Pain·Amrita Prasad Md, Krishnan Chakravarthy Md
May 14, 2021·Pain Reports·Michael J LacagninaPeter M Grace

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