PMID: 2491876Jan 1, 1989Paper

Cutaneous inflammation: effects of hydroxy acids and eicosanoid pathway inhibitors on vascular permeability

The Journal of Investigative Dermatology
J S WaldmanH W Lim

Abstract

Four metabolic products of arachidonic acid lipoxygenation, 5-hydroxyeicosatetraenoate (5-HETE), 12-HETE, 15-HETE, 5(S),12(S)-DiHETE, were injected intradermally into depilated dorsae of albino guinea pigs. The presence of intravenously injected 125I-bovine serum albumin (10uCi/kg) in 13-mm punch biopsy specimens served as a marker for altered vascular response; histologic changes were evaluated at 6 and 24 h after the injection in 1-micron-thick sections. Thirty minutes after the injections of 15 nanomoles and 60 nanomoles of 5-HETE, the ratios of radioactivity in HETE-injected to that in buffer-injected sites were 1.35 +/- 0.06 (mean +/- SE) and 2.80 +/- 0.27, respectively. Corresponding effects of 15-HETE were 1.39 +/- 0.17 and 1.63 +/- 0.21, respectively. Values for 60 nanomoles of 12-HETE and 5,12-DiHETE were intermediate in comparison with the above eicosanoids. The most notable histologic changes were a neutrophilic infiltrate induced by 12-HETE at 6 and 24 h, and neutrophilic and eosinophilic infiltrates in response to 5,12-DiHETE injection at 6 and 24 h. Effects of topically applied eicosanoid pathway inhibitors were also evaluated, using intradermally injected sodium arachidonate (AA) as agonist. Three mixed cyclooxyg...Continue Reading

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Citations

Apr 16, 1998·The Journal of Investigative Dermatology·R AntónL Vila
Dec 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D J Fretland, S W Djuric
Jan 1, 1994·The Journal of Investigative Dermatology·N GodessartJ M de Moragas
May 18, 2005·Microvascular Research·Natalia V BogatchevaAlexander D Verin

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